ID A0A1I5Y122_9BACT Unreviewed; 882 AA.
AC A0A1I5Y122;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Topoisomerase-4 subunit A {ECO:0000313|EMBL:SFQ37941.1};
GN ORFNames=SAMN04515674_11696 {ECO:0000313|EMBL:SFQ37941.1};
OS Pseudarcicella hirudinis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Pseudarcicella.
OX NCBI_TaxID=1079859 {ECO:0000313|EMBL:SFQ37941.1, ECO:0000313|Proteomes:UP000199306};
RN [1] {ECO:0000313|EMBL:SFQ37941.1, ECO:0000313|Proteomes:UP000199306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E92,LMG 26720,CCM 7988 {ECO:0000313|Proteomes:UP000199306};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; FOXH01000016; SFQ37941.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5Y122; -.
DR STRING; 1079859.SAMN04515674_11696; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000199306; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFQ37941.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199306};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 13..447
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 832..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 419..446
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 882 AA; 100327 MW; F341C332ADCE47AE CRC64;
MENQQDDALH EQIAVAGMYE NWFLEYASYV ILERAVPAVE DGLKPVQRRI LHALREMDDG
RFNKVANVIG QTMQYHPHGD ASINEAMVNM GQKDLLFDCQ GNWGDVRTGD GAAAARYIEV
RLSRFANEVV FNNQTTEWQL SYDGRKKEPI SLPVKFPLLL AQGVEGIAVG LATKIMPHNF
CELVEASIDI LKNKNIEIYP DFQTGGAIDV SIYNDGQRGG KIRVRAKIEE IDKKTLAIRE
IPFSTTTTSL IDSIIKANDT GKIKIKKVID NTAKDVEIQV QLAPGTSPDV TIDALYAFTD
CEISISPNAC VIIADKPHFV GVSDILKTCT HQTVRLLERE LEIRKEELME KVLFSSLEKI
FIENRIYRKI EECETFEEVI KTVDEGLEPY KADFYREIVE DDILRLLEIR IKRISKYDSF
KADELMKRLQ EELLEVEDNL AHIIRYSIDY FKDLLKKYGK GRERKTEIRN FNTITAAVVA
AANQKLYVNR EDGFIGYGLK KDEYVMDCSD IDDIIVFRRD GRCLVTKIQD KVFVGKDIIH
CAVFKKNDDR KVYNLAYFDA KTGVSYVKRF KVTAVTRDRE YDLTAGNPKS KITYFSANEN
GEAEIIQINL TASCTAKIKQ FDYDFSKLMI KGRDSLGNVL TKFPVRKISL KSAGVSTLGG
VDIWYDSTVG RLNRDEHGRY LGNFNAKDNI LVVYNDGQYE LTNFELTNRY ESKEISVLAR
FTPDKIITAV YYDGGSKTYF VKRFRIETTT IDKKFLFISD EKGSKLISAS IDLYPRIELS
FKKDEKNAVL EKEEINLDEL AEVRGWKAQG SKLTGFKVQH IKVLEPRLVT PTVSEATEEQ
ETESTAEEQE IENDSAVKLT PPEEIEFPDS GETGTGEQLG LF
//
