ID A0A1I5Y3J3_9LACT Unreviewed; 640 AA.
AC A0A1I5Y3J3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Cd(2+)-exporting ATPase {ECO:0000256|ARBA:ARBA00039103};
DE EC=7.2.2.21 {ECO:0000256|ARBA:ARBA00039103};
GN ORFNames=SAMN04488506_1766 {ECO:0000313|EMBL:SFQ38812.1};
OS Desemzia incerta.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae; Desemzia.
OX NCBI_TaxID=82801 {ECO:0000313|EMBL:SFQ38812.1, ECO:0000313|Proteomes:UP000199136};
RN [1] {ECO:0000313|EMBL:SFQ38812.1, ECO:0000313|Proteomes:UP000199136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20581 {ECO:0000313|EMBL:SFQ38812.1,
RC ECO:0000313|Proteomes:UP000199136};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:48775,
CC ChEBI:CHEBI:456216; EC=7.2.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00036510};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; FOXW01000006; SFQ38812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5Y3J3; -.
DR STRING; 82801.SAMN04488506_1766; -.
DR OrthoDB; 9813266at2; -.
DR Proteomes; UP000199136; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02079; P-type_ATPase_HM; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR48085; CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED; 1.
DR PANTHER; PTHR48085:SF5; CADMIUM_ZINC-TRANSPORTING ATPASE HMA2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cadmium {ECO:0000256|ARBA:ARBA00022539};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000199136};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 63..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 86..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 567..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT REGION 620..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 68970 MW; 75FF83ABAE5D2320 CRC64;
MQQYVLSKKS KITWISGMLI IIGFFSHFVL KNVWVSEGAL IVASILGVAP IAIQAVQALK
VKVVSIDVLV TIAVIGAFLI QNYEESAIVT FLFLFGHFLE QRTLNQTRSA IKELTEMAPE
SALRQMEDGA FEEVEVDAVD EGDILLVKTG AKVPVDGTVL SGEGHINEAS ITGESVPVNK
TAGAEVYAGT ILENGTLQIR ADRVGEDTTF GKIIELVEEA QDSKSEAERF IDRFSKYYTP
AVLVLSFAVW LFSQDIELAI TILVLGCPGA LVIGVPVSNV AGIGNGARNG VLLKGSEVIH
DFSRVDTIVF DKTGTLTQGN PAVAEMEFYD GQAEEVLGYL ASVERESDHP LAKAVLQEIG
ETTFSIVEDT KVVKGGGITA QVNGHRVAVG NAALMEQEHV LMDQKAQADI RRFGKNGNSL
VLTAVDGELK ILMGIRDQVR VGVKKDLEEL KQLGVKNLIV LSGDNQGTVD VVARELELTE
AHGNMLPEDK AAYIAELQQQ GQIVAFVGDG VNDSPSLALA DIGIAMGKGT DVAIETSDVV
LMNSDFSRLP HALGLTKATA RNMKQNIIIA VGVVAVLMAS VFFSEWMNMS IGMLVHEGSI
LVVIFNGMRL LRYQLNGNRR RSGYTTSSSN EVVKTPLRTL
//
