ID   A0A1I5ZWH2_9PSEU        Unreviewed;       128 AA.
AC   A0A1I5ZWH2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   ORFNames=SAMN05421810_110188 {ECO:0000313|EMBL:SFQ60831.1};
OS   Amycolatopsis arida.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=587909 {ECO:0000313|EMBL:SFQ60831.1, ECO:0000313|Proteomes:UP000198727};
RN   [1] {ECO:0000313|Proteomes:UP000198727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.5579 {ECO:0000313|Proteomes:UP000198727};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An RNase.
CC       {ECO:0000256|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00265};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000256|ARBA:ARBA00038093, ECO:0000256|HAMAP-Rule:MF_00265}.
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DR   EMBL; FOWW01000010; SFQ60831.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5ZWH2; -.
DR   STRING; 587909.SAMN05421810_110188; -.
DR   OrthoDB; 286092at2; -.
DR   Proteomes; UP000198727; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd18682; PIN_VapC-like; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR022907; VapC_family.
DR   Pfam; PF01850; PIN; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00265};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00265};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00265};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00265};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198727};
KW   Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW   Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649, ECO:0000256|HAMAP-
KW   Rule:MF_00265}.
FT   DOMAIN          4..118
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|Pfam:PF01850"
FT   BINDING         6
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
FT   BINDING         93
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
SQ   SEQUENCE   128 AA;  13223 MW;  FBD0BD0BC4A11CBD CRC64;
     MTAVLDASAV LALLRAEPGH EQVAELVPGS VISAVNYSEV VQKLAQLGSD TAEDDAAALV
     ALGTTVAAFD VRAATNAARL WPATRRAGLS LADRACLALA ADLADGVAVT ADRAWAELGL
     DIRVRFIR
//