ID A0A1I6BL62_9BACI Unreviewed; 729 AA.
AC A0A1I6BL62;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN04488577_2077 {ECO:0000313|EMBL:SFQ81678.1};
OS Bacillus sp. cl95.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1761761 {ECO:0000313|EMBL:SFQ81678.1, ECO:0000313|Proteomes:UP000199578};
RN [1] {ECO:0000313|EMBL:SFQ81678.1, ECO:0000313|Proteomes:UP000199578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL95 {ECO:0000313|EMBL:SFQ81678.1,
RC ECO:0000313|Proteomes:UP000199578};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FOYF01000002; SFQ81678.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6BL62; -.
DR STRING; 1761761.SAMN04488577_2077; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000199578; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFQ81678.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199578};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..142
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 729 AA; 83744 MW; D309F092554BF611 CRC64;
MSRVIIAEKP SVAKNIAEAL KIRGRNDGYF EGNGYFITWA FGHLLQLYDA KDYDEKMAKW
NMDNFPFIPP YFRYKVKSDP KNKGKEDLGA KKQLKIIYNL IKRDDVDMII SACDFDREGQ
IIGDTIIYNL KTQKQVFRLL LNEWTPDEVL KGLQQIKPNS EMRSLQDAGI GRQWADWVIG
INLTSVATLK YQKGKGKALN IGRVLMPTLK IIYDRDKAIE NFEPDQYFKL AGSFKTDEGK
EYEGTYFENE EDKFKNKDSL ELIKQALLNQ TATINDKQVE LKREYPPFLF NLSNLQGFIT
SKYKGWTSDK VLKVAQSLYE KKYITYPRTA SVVLEESLVG KAAKVLENLK RGLPYEHEIN
FIKHKRVFDN SKVDSHSAII PTYLIPKSLT REEEIVYTAI KNRFIMQFMP IAEHEETKIY
TRINNSKING IFISRGKVQL VDGWKKVEKI ESKDTILPLV RVNDSVSIID YNLSSHTTKP
PKHHTEKTLL RVMETCGKGQ EDEESEEMMA AILSGYSIGT PATRAETIKK LKDVGYIDTQ
NKNLICTELG KRLIETFPVK ELFDLEFTGR LEKTLSDIEK RKFTKESFLD LIFDFTTKSV
ATIKNERDII IHEVSYENKS VEVLGKCPIC GNGVVEGQKG FGCSNWKNGC KFVIWKNDKF
LATMKKKPTK TLVKALLKNG TGIVKGLTSK KGNKFDANLR YEKNPDNEYF SWKMEFLNST
PKNNTKDIG
//
