ID A0A1I6CTJ5_9FIRM Unreviewed; 596 AA.
AC A0A1I6CTJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Chloride channel protein, CIC family {ECO:0000313|EMBL:SFQ96554.1};
GN ORFNames=SAMN05660706_10221 {ECO:0000313|EMBL:SFQ96554.1};
OS Desulfoscipio geothermicus DSM 3669.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfoscipio.
OX NCBI_TaxID=1121426 {ECO:0000313|EMBL:SFQ96554.1, ECO:0000313|Proteomes:UP000199584};
RN [1] {ECO:0000313|Proteomes:UP000199584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3669 {ECO:0000313|Proteomes:UP000199584};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOYM01000002; SFQ96554.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6CTJ5; -.
DR STRING; 39060.SAMN05660706_10221; -.
DR OrthoDB; 9812438at2; -.
DR Proteomes; UP000199584; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199584};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..511
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 517..576
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 596 AA; 63855 MW; 07E61CBA45976EEE CRC64;
MVSTNKELRK SGNSNKLYEQ FYRVALALVI GILTGLGAVA FRKLISFFHN GFFDHGGQLL
SFLGQYYVII IPMAGGLIVG PLTYFFAREA KGHGVPEVMA AVAVRGGRIR PRIVLVKALA
SAVCIGSGGS VGREGPIVQI GSAIGSTVGQ VFKVSTRKMR ALVACGAAGG IAATFNAPIG
GVLFALEIIL GDFTGDHLML VIISSVTSAV ISRIMLGNDP AFIVPAYPLS HPVELLLYAL
LGVVCGIFAV VYIRVLYKSE DIFDSIKIIP EYLKPVLGGF LIGAIGLKFP QIFGVGYESI
EMAITGNMIF SITAALVLLK LLATSITIGS GGSGGVFAPG LFMGSMLGAS MGYVFHYLFP
NIAITPAAYA LVGMGSVFAG SAHAPITAII MLFEMSNDYH IILPLMIACV ISSVVAKTVY
HNNIYVVKLV RRGLDIEAAR RPDVLKNVLV KDVMTSRIET IPCKFTIKEA RKLVHGSPHR
GFPVVTEDGY ICGIVTSNEL ERAFTEGDID KQVNELAVHH LVTVTPYEPI SVAARRMVEY
DIGRLPVVDP DNAEKIIGLL SRTDIISAYS KGLLQEDNLE ESFVSKHITD IETLKG
//
