ID A0A1I6D3Y9_9FIRM Unreviewed; 726 AA.
AC A0A1I6D3Y9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN ORFNames=SAMN05660706_1058 {ECO:0000313|EMBL:SFR00100.1};
OS Desulfoscipio geothermicus DSM 3669.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfoscipio.
OX NCBI_TaxID=1121426 {ECO:0000313|EMBL:SFR00100.1, ECO:0000313|Proteomes:UP000199584};
RN [1] {ECO:0000313|Proteomes:UP000199584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3669 {ECO:0000313|Proteomes:UP000199584};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOYM01000005; SFR00100.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6D3Y9; -.
DR STRING; 39060.SAMN05660706_1058; -.
DR OrthoDB; 9806952at2; -.
DR Proteomes; UP000199584; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199584};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 496..639
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 705..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 79087 MW; E50606FFBD9C8845 CRC64;
MLPLGKARGK IIASYNRLAG KRKVRRGVAA LIFFVALTLL ISVEFMPQKV NLVVGQVSPT
DVFAPRSIIF EDKIKTEEAR NLAATQIEKQ YITDPRVSVD VQQNISALID AVGTIQSNKE
LSEDAKVSKL QEVIPFDLTS DTVKLLALPN PENLNRMEAG LTAMVTRTME SQQGVTQENI
DDIEAGLIAE IKNLQLQSPY EKLATEIISY YLRPNKFFDA EKTQRLQQAA REAVPPVMVT
IKEREKIIGE GEIVTEEHLA KLEALGLSRP TLPISSIVGS ALLVALLMLV VLFYLYQQNR
EIYKNAGHLY LLGIIVLGVL GVSKAIIAIN VTQWPEFGAL FGYLAPVAAA GMLIAILLDS
RLAVLVVAVM SILLGLMTGG QIRFAVVGLI GGMTGVYGVS KLSQRGDLAR AGFYTGAANI
AAIFAMGLIG DTSIGLVVTS SLALGSVNGI LSSILTNGAI PYLESAFGIT SAVRLLELSN
PGNPLLRRLQ IEAPGTYHHS LLVGNLAESA ADAVGGDSLL VRVAAYYHDI GKMKRPYFFI
ENQMGENPHD KIAPSLSTLI LTSHVKDGSE MARENKLPQG IKEIIEQHHG TSLCSFFYHK
AVENNKNENI TEDDFRYEGP KPQTKEAAIV MLADTVEAAV RSMQNRTPGR TEGLVRKIIR
DKLMDGQLDE SDLTLKDLDA IANAFIRVLS GIFHSRIEYP DMAKEMERRK SKRAGARKQS
AGKSVG
//
