ID A0A1I6DEL5_9FIRM Unreviewed; 214 AA.
AC A0A1I6DEL5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase {ECO:0000313|EMBL:SFR03905.1};
GN ORFNames=SAMN05660706_109115 {ECO:0000313|EMBL:SFR03905.1};
OS Desulfoscipio geothermicus DSM 3669.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfoscipio.
OX NCBI_TaxID=1121426 {ECO:0000313|EMBL:SFR03905.1, ECO:0000313|Proteomes:UP000199584};
RN [1] {ECO:0000313|Proteomes:UP000199584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3669 {ECO:0000313|Proteomes:UP000199584};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOYM01000009; SFR03905.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6DEL5; -.
DR STRING; 39060.SAMN05660706_109115; -.
DR Proteomes; UP000199584; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:SFR03905.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199584};
KW Transferase {ECO:0000313|EMBL:SFR03905.1}.
FT DOMAIN 1..90
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 90..214
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 214 AA; 23406 MW; 19090602348FAB34 CRC64;
MMQNFSSIAQ AVIEGDVGRV QELVNFALGT KLCTPEELLT FHLLPGMDEI GRQFKANEIH
IPEVLLSSRA LQAGVIKIKH YFPDNSAQEK AKVLLGTVAG DLHDIGKRLV GIFLKSSGFQ
VIDVGIDVAP EDFVRYVKEY QPDVLGMSAL LNTTMIWMGE TIKLLKKQKL IHNCKVIVGG
NPVTPEFARQ IGADGYAETA LDAVSCTNKL LGLQ
//
