ID   A0A1I6DJ27_9FIRM        Unreviewed;       648 AA.
AC   A0A1I6DJ27;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Acetyl-CoA synthetase {ECO:0000313|EMBL:SFR05439.1};
GN   ORFNames=SAMN05660706_11222 {ECO:0000313|EMBL:SFR05439.1};
OS   Desulfoscipio geothermicus DSM 3669.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC   Desulfoscipio.
OX   NCBI_TaxID=1121426 {ECO:0000313|EMBL:SFR05439.1, ECO:0000313|Proteomes:UP000199584};
RN   [1] {ECO:0000313|Proteomes:UP000199584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3669 {ECO:0000313|Proteomes:UP000199584};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOYM01000012; SFR05439.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6DJ27; -.
DR   STRING; 39060.SAMN05660706_11222; -.
DR   OrthoDB; 9778383at2; -.
DR   Proteomes; UP000199584; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199584}.
FT   DOMAIN          16..72
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          81..466
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          531..609
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   648 AA;  71924 MW;  863D5B935539F29B CRC64;
     MEKNKVGTGL IPPHVRKFID WAAEDTEGFW GHAAEQAMSE IKWFKKWDQV FQWDYPTFRW
     FIGGQTNISY NCLDYNIEKG RAGRAAIVAE SGETGEVRTV TYAQLFELVK QYARALRGLG
     VKKGDRVAVY MPTGIESVAA MLACARVGAI HVVIFAGFSS NAVADRLQIS GARYVLAQDE
     GSRRGKPVEL KPIVDEGIAK CPPDLIQKVV VLRKNPDREY PMTEGRDIYW DEFLAGGEGQ
     SDAYEIMDSN DPLFLLPTSG TTAKPKVTVQ KHGGYQIYIY SMGKWIYGLR DSDVWFCTSD
     IGWIVGHSYN VYCPLLTGCT TVLYEGTPDY PNKDMWWSVA SRNKATALWL SPTGVRGLMR
     LGIDEARKHD LSSVERIFCA GEVLNPPAWS WLQEQVFENK VPVMDHMWQT ETSGPIFANP
     YGLGIIPIKP GSAHIPVPGV VAEVLDEKDG NPLPPGEKGV VVIKKPFPGL VSTLWGDPEG
     YLYNYWERLP VTKGKYLCGD AAYMDEDGYI FFAGRSDEVI KIAAHRIGTV EVESALIGHP
     AVVEAGVSGV PDELRGEVAC AFVVLKQGYE PSEEMKKELI AHVRNTMGAI VVMRDIQFVG
     TLPKTRSGKI MRRVMKTLWS GKELGDLSTI EEEASIAEIK EAIDKMKG
//