ID   A0A1I6DR84_9FIRM        Unreviewed;       296 AA.
AC   A0A1I6DR84;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:SFR07877.1};
GN   ORFNames=SAMN05660706_11565 {ECO:0000313|EMBL:SFR07877.1};
OS   Desulfoscipio geothermicus DSM 3669.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC   Desulfoscipio.
OX   NCBI_TaxID=1121426 {ECO:0000313|EMBL:SFR07877.1, ECO:0000313|Proteomes:UP000199584};
RN   [1] {ECO:0000313|Proteomes:UP000199584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3669 {ECO:0000313|Proteomes:UP000199584};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
CC   -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC       family. {ECO:0000256|RuleBase:RU003523}.
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DR   EMBL; FOYM01000015; SFR07877.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6DR84; -.
DR   STRING; 39060.SAMN05660706_11565; -.
DR   OrthoDB; 9784013at2; -.
DR   Proteomes; UP000199584; Unassembled WGS sequence.
DR   GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:SFR07877.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199584};
KW   Transferase {ECO:0000256|RuleBase:RU003523}.
FT   DOMAIN          7..277
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   296 AA;  31030 MW;  E2C32260846B4CE9 CRC64;
     MHWPGKVLVR EVGLRDGLQN EKTVLPTEKK IALIRELTGA GISAIEATSF VHPRAVPQLA
     DAEAVLAGIG APGPGVTISA LVGNVKGMQR ALEMLHTPLR EIVVVVSASE AHNRANLNRS
     VAESLAELVE ICRLAEGRLR VRGAVATAFG CPYQGAIGIY AVARVIEGMV AAGIREITLA
     DTAGMGNPRQ VYDLAGEVGE RYSGVDWALH LHDTRGLGLA NALAGVLAGV TILECSLGGL
     GGCPFIPGAT GNVATGDLVH MLHKMGVETG MDLRRVLQCT ASLERLLGRN LPARIR
//