ID A0A1I6FFJ1_9PSEU Unreviewed; 585 AA.
AC A0A1I6FFJ1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Beta-ketoacyl synthase, C-terminal domain {ECO:0000313|EMBL:SFR28700.1};
GN ORFNames=SAMN04488564_1158 {ECO:0000313|EMBL:SFR28700.1};
OS Lentzea waywayandensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=84724 {ECO:0000313|EMBL:SFR28700.1, ECO:0000313|Proteomes:UP000198583};
RN [1] {ECO:0000313|EMBL:SFR28700.1, ECO:0000313|Proteomes:UP000198583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44232 {ECO:0000313|EMBL:SFR28700.1,
RC ECO:0000313|Proteomes:UP000198583};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; FOYL01000015; SFR28700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6FFJ1; -.
DR STRING; 84724.SAMN04488564_1158; -.
DR Proteomes; UP000198583; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 18..442
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 585 AA; 62559 MW; 0DFD1DFB88CD0457 CRC64;
MSTKMPEHAS SWGGASGDQA IAVVGMSCRF PGANNVAALW QLLREGMDAT SETPAERYDA
KAMYSPRPAP GKVISFRSGY VDGIADFDAE FFDMSENEAR SLDPQQRLLL MTAWEAFEDA
GQVPSALAGS RTGVYVGSMH LDYWDLVAKR GIEAINPSSV YNQRSVLSGR LSYTFDLRGP
SVTLDTACSS SLVAVHLACQ SLRLGETNIA LAAGVNLKLI PDEDVLLSQV RMLAPDGRCK
FGDASANGFA PSDGVGVVVL KRLADALADG DRVHAVVLGS AVTNDGASSG SLLAPSVEGH
VQMLRWAYEN AGVRPGEVDF VEAHGTGTPM IDPIEFAGLS EVLGEERDQD RPLLVGSVKS
NIGHTEGAAG IAALIKTALC LRHRQVVPSL HHHTPNPKVP WSELPVRVPT EPHPIVPVGR
LAIAGISGQG ISSVNCHLVV GEADPMWRRA SKAHVTRTLP FAVSARTPAA LDDMLRRYIT
YLSPGGQGRQ ESLLDVCFSA ATSREHHAHR LVFDATTADE LVDRMERHLA GQADVEAATV
TAAVYRAGGS PDWAEVFEGE GQVVSLPHYS WQTINYWLDD VAVTS
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