ID   A0A1I6FH22_9PSEU        Unreviewed;       918 AA.
AC   A0A1I6FH22;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SFR29215.1};
GN   ORFNames=SAMN04488564_11813 {ECO:0000313|EMBL:SFR29215.1};
OS   Lentzea waywayandensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Lentzea.
OX   NCBI_TaxID=84724 {ECO:0000313|EMBL:SFR29215.1, ECO:0000313|Proteomes:UP000198583};
RN   [1] {ECO:0000313|EMBL:SFR29215.1, ECO:0000313|Proteomes:UP000198583}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44232 {ECO:0000313|EMBL:SFR29215.1,
RC   ECO:0000313|Proteomes:UP000198583};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOYL01000018; SFR29215.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6FH22; -.
DR   STRING; 84724.SAMN04488564_11813; -.
DR   Proteomes; UP000198583; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        266..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        459..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          521..717
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   REGION          815..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   918 AA;  95879 MW;  9BBC6FE8B4147095 CRC64;
     MSRKHSIAHD YRLVPAAAAV WTTAVAGLFL SWQAAAITGL AAGAIGLAAW RRAWWTKTCA
     IALLISGPLA AAWVGGHVLR AESHPLRLAA NEGRSTTLTV ELTTRPKGIR AAGFGGTQAG
     VENVVIRATA NGAQLVLLAP AAKWRDLLPG QKVTVKGTLA PPRGGDLASA LLRVRGPPGN
     PRPPPVWQTW ADELRDGLRQ ASTVLDDEEA GLLPALVVGD TEQMVPRIVD EFRTAGLSHL
     LAVSGANLAI VCGAVYLLTR RLGPRPAALA AMAALVGFVI LAGPEPSVLR AAVMGAVALL
     ALVLGRQRSA VPSLATAVFV LVLHDPALGG DPGFALSVVA TAALVLVAPR WARALKRRGV
     PNGLAEAIVV PMAASLATAP LVAGLSGQVS LVSVVANLVA GPVVAPATVL GVMAAAIAPL
     SPRAAEVITH VAGPAVTWLI QVGRQAASVP GAAVGWPDGW AGAIALAAVT AAVVLLLRFK
     KTRTLVVAVL VGVFVVLVPV RVVAPVWPPD GWKVVSCDVG QGDALVLATD TADTAVVVDT
     GPDPGAADRC LKTLGIKKIP LVVLTHLHAD HIGGLDAVLT GRAVGAVAVG PLKEPAWAWR
     EVGERARAQH VRVVEPKAGE RFALPGLELE VLGPRRPPVA QDENTTVNDY SLVLKAHTRA
     GRVLLTGDVE LAGQAALLGE RDLNAEVLKV PHHGSRYSLP AFLKAVRPRV ALVSVGTGNR
     YGHPSPHVID VLRTGGALVL RTDKDGDLAV LPGNRIVRRR RDGLGQVVQR ALPDSRWHAR
     ARMGAVADEL LGDAVAARRA QTRFRLLRLR NARRRHTRRH VPGDDHTCAA ADEGRDSGGG
     VRPRRGARVR RRSADRAGRL ARLPLQRAQG GSPVAATDRG VARERGTGRA TRRGRPATLP
     AHGLAQDGRD LPVSRRVQ
//