ID A0A1I6IFJ4_9FIRM Unreviewed; 232 AA.
AC A0A1I6IFJ4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN ORFNames=SAMN05661086_00800 {ECO:0000313|EMBL:SFR65453.1};
OS Anaeromicropila populeti.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaeromicropila.
OX NCBI_TaxID=37658 {ECO:0000313|EMBL:SFR65453.1, ECO:0000313|Proteomes:UP000199659};
RN [1] {ECO:0000313|EMBL:SFR65453.1, ECO:0000313|Proteomes:UP000199659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=743A {ECO:0000313|EMBL:SFR65453.1,
RC ECO:0000313|Proteomes:UP000199659};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677,
CC ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606,
CC ECO:0000256|RuleBase:RU362042}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606, ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
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DR EMBL; FOYZ01000002; SFR65453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6IFJ4; -.
DR STRING; 37658.SAMN05661086_00800; -.
DR OrthoDB; 6194834at2; -.
DR Proteomes; UP000199659; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019533; Peptidase_S26.
DR InterPro; IPR027383; Znf_put.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR Pfam; PF13490; zf-HC2; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042};
KW Membrane {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Reference proteome {ECO:0000313|Proteomes:UP000199659};
KW Transmembrane {ECO:0000256|RuleBase:RU362042};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT DOMAIN 6..40
FT /note="Putative zinc-finger"
FT /evidence="ECO:0000259|Pfam:PF13490"
FT DOMAIN 86..231
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 110
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 150
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 232 AA; 26183 MW; 89C60189A0894B1E CRC64;
MENKICAVIR DILPLYCDNA VSEESKKIIE GHLEGCEGCR QYKKELKEAG NVNVSNNKNA
ISNETANIKQ IADRLRRRKR NIVIGVSAAF VLALIVLSQI FQISVIAGTS MEPTYSDKQD
IIINRMSYRF SSPKRGDIIY FSHNDVLSIK RVIGLPEETI ELKNGKLYID GELLEENYFD
REVGNPGDIT YPVTLGNDEY FVIGDNLDNS LDSRQSAYGM IQRDEVLGKV IR
//
