ID   A0A1I6JC03_9MICO        Unreviewed;       402 AA.
AC   A0A1I6JC03;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Acetyl-CoA acyltransferase {ECO:0000313|EMBL:SFR76525.1};
GN   ORFNames=SAMN05428970_2085 {ECO:0000313|EMBL:SFR76525.1};
OS   Agromyces sp. CF514.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Agromyces.
OX   NCBI_TaxID=1881031 {ECO:0000313|EMBL:SFR76525.1, ECO:0000313|Proteomes:UP000199174};
RN   [1] {ECO:0000313|EMBL:SFR76525.1, ECO:0000313|Proteomes:UP000199174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF514 {ECO:0000313|EMBL:SFR76525.1,
RC   ECO:0000313|Proteomes:UP000199174};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FOZD01000001; SFR76525.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6JC03; -.
DR   STRING; 1881031.SAMN05428970_2085; -.
DR   OrthoDB; 1402717at2; -.
DR   Proteomes; UP000199174; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:SFR76525.1};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SFR76525.1}.
FT   DOMAIN          7..257
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          268..390
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        95
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        347
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        378
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   402 AA;  42649 MW;  305E96F9484474C4 CRC64;
     MAHQADVVFV DGVRTPFGKA GEKGMYWNTR ADDLVVKAIV GLLERNPNVP KDRIDDVAIA
     ATTQTGDQGL TLGRTAAILA GLPKTVPGFS IDRMCAGAMT AAAMVSGSIG FGMYDLAIAG
     GVEHMGHHPM GSGVDPNPRF LSERLVGEDA LVMGATAERI HDRFPQLTKE RSDRFALASQ
     QKTAAAYAAG KIQQDLVPVA IRTEQGWGLA THDEVMRPET TLEGLAGLKT PFRPHGRVTA
     GNASGLNDGA TAALLASGDT AKELGLAPKM KLVSYAFAGV DPEIMGIGPI PATEKALRKA
     GLTIDDIDLF EMNEAFAVQV LSFMDHYGID DEDPRVNPWG GAIAVGHPLA SSGVRLMNQL
     ASQFAERPEL RYGITSMCVG LGQGGTMIWE NPNFDKKAKK RA
//