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Entry: A0A1I6KLB8_9MICO
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ID   A0A1I6KLB8_9MICO        Unreviewed;       437 AA.
AC   A0A1I6KLB8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=SAMN05428970_3873 {ECO:0000313|EMBL:SFR92007.1};
OS   Agromyces sp. CF514.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Agromyces.
OX   NCBI_TaxID=1881031 {ECO:0000313|EMBL:SFR92007.1, ECO:0000313|Proteomes:UP000199174};
RN   [1] {ECO:0000313|EMBL:SFR92007.1, ECO:0000313|Proteomes:UP000199174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF514 {ECO:0000313|EMBL:SFR92007.1,
RC   ECO:0000313|Proteomes:UP000199174};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; FOZD01000003; SFR92007.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000199174; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199174};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:SFR92007.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      115    320       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   437 AA;  45509 MW;  4617F5AECB92AB42 CRC64;
     MRILILGSGA REHAIILALL DEEAGHEIVA APGNAGIAAS ATSSARGSVE TIALDPTDRS
     VVTEYALEND IDLVVVGPEA PLVAGVADAL RTRGIPVFGP GKAAAALEGS KTFAKRIMED
     ANVPTGRARL AETLADVEAT LDEYGAPHVV KADGLAAGKG VLVTEDRDAA LAHAAHYLQQ
     GPVLVEEFLD GQEVSLFLLS DGTNVLPLSP AQDYKRLRDG DQGPNTGGMG AYSPLPWLDA
     EFGSEQAFVD EVIETIALPT VKQLADEQTP FIGLLYAGLI LTTRGIRVIE FNARFGDPET
     QVVLPRLATP LSSLLLAAST GGLGELPRPE FRPDAAVTVV LASEGYPEAP ETGRAIEGLD
     AAASVPGVHI AHAATAIGSV TEPDVDPPLI ATGGRVLNVV AVGEDFGEAR RRAYEALGHL
     RLEGGQYRTD IAARVAE
//
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