ID A0A1I6KR87_9BURK Unreviewed; 552 AA.
AC A0A1I6KR87;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05428960_3515 {ECO:0000313|EMBL:SFR93508.1};
OS Mitsuaria sp. PDC51.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=1881035 {ECO:0000313|EMBL:SFR93508.1, ECO:0000313|Proteomes:UP000199246};
RN [1] {ECO:0000313|EMBL:SFR93508.1, ECO:0000313|Proteomes:UP000199246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PDC51 {ECO:0000313|EMBL:SFR93508.1,
RC ECO:0000313|Proteomes:UP000199246};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOZE01000002; SFR93508.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6KR87; -.
DR STRING; 1881035.SAMN05428960_3515; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000199246; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFR93508.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199246};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..193
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 552 AA; 60319 MW; 77BC5DCA180C0B38 CRC64;
MSLDGLEDRK ARGAFFTPPE IARFMVDWAV RSKGDAVLEP SCGEAAFLLP AARRLHALGA
TKRAISQQLE AGDIHQASVE EAQKVLAREG FGAKTDVGDF FLKSASPSFD AVVGNPPYVR
YQQFGGASRA ASLQAALRQG VRLTQLASSW AAFTVHASAF LRPEGRLALV IPAELLSVKY
ATQIRRFLLD RFASVRLVLF ETLVFPGVLE DVVLLLAEGS GGAQSFEVFQ ARSAADLATK
LPAQWLKFKP ATDDKWTGAL LSTDAYRLYD EAVGSADIET MSAWGSTYLG AVTGNNDFFT
LSEVDVERMK LGSAELMKIS PPGARHLRGL NFSAQAWRSM VKGGERCYLF KPGSEPSKAA
RDYIAYGESL GVHNAYKCRV REPWWVVPVV AKPDLLMPYM NHDRPRLVRN GAGIQLLNSI
YGVKLEATRR KLGQELLPLA MLNSLTLLGS EIVGRAYGGG MLKHEPTEAG KIPLPSHAAL
EAMADPLKSV QDCVNSLLER NEVEAAASVV DDVFLRKRLG WTESRLKAIR EARATLVQRR
LTRGKGKNGS DR
//
