ID A0A1I6KTK4_9MICO Unreviewed; 476 AA.
AC A0A1I6KTK4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:SFR94556.1};
GN ORFNames=SAMN04487846_0977 {ECO:0000313|EMBL:SFR94556.1};
OS Microbacterium sp. cf046.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1761803 {ECO:0000313|EMBL:SFR94556.1, ECO:0000313|Proteomes:UP000199422};
RN [1] {ECO:0000313|EMBL:SFR94556.1, ECO:0000313|Proteomes:UP000199422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF046 {ECO:0000313|EMBL:SFR94556.1,
RC ECO:0000313|Proteomes:UP000199422};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; FOZJ01000001; SFR94556.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6KTK4; -.
DR STRING; 1761803.SAMN04487846_0977; -.
DR OrthoDB; 9775207at2; -.
DR Proteomes; UP000199422; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR30566:SF25; INNER MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR30566; YNAI-RELATED MECHANOSENSITIVE ION CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199422};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..416
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 476 AA; 51672 MW; 61FD940456FB392B CRC64;
MADIVSQPWF WPAVIVSVGL PLLLIGLTEM HNAMARRGSR AAPIVLMVRN YLVPVAGVLV
LISQPGAWEG EGTWPKVVTT IFGLLVILVV INAINHLVFH RAEKGSWRDR FPTIFSDLIR
FVFILVGIAL LFWWVWGADV AGIFAALGVT SIVVGLALQN AVGSVVSGLF LIFEAPFQLG
DWIETGDVRG QIIEVNWRAI HLDVGNGTVV MPTSELAGGS FTNLSRSPEP YAAQRAFSFA
TDDPPARVRA LLVDVARDIP LVSADRDPSV ATLDGAQFQV SIPLQSPGDK DVVLDAFSTR
LWYAARRADL HLNGDVTDEW NTPGRLQDAL HQIAPILSLR PEDAEALAVS ARLERFCQGE
VILRPGMIPT ATRYILAGRV MLGIPTDAGL VQVTELGRDD AVGLTALTRT QTISRAIALT
ELEVLTIPVH LLDDVVRAHP VLAREIVREN DNRVRLARSA LAAVGEHLAP GRNVFG
//
