ID   A0A1I6KWP6_9BURK        Unreviewed;      1084 AA.
AC   A0A1I6KWP6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Multidrug efflux pump {ECO:0000313|EMBL:SFR95641.1};
GN   ORFNames=SAMN05428960_4108 {ECO:0000313|EMBL:SFR95641.1};
OS   Mitsuaria sp. PDC51.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Roseateles.
OX   NCBI_TaxID=1881035 {ECO:0000313|EMBL:SFR95641.1, ECO:0000313|Proteomes:UP000199246};
RN   [1] {ECO:0000313|EMBL:SFR95641.1, ECO:0000313|Proteomes:UP000199246}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PDC51 {ECO:0000313|EMBL:SFR95641.1,
RC   ECO:0000313|Proteomes:UP000199246};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOZE01000002; SFR95641.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6KWP6; -.
DR   STRING; 1881035.SAMN05428960_4108; -.
DR   Proteomes; UP000199246; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF21; MULTIDRUG RESISTANCE PROTEIN MDTB; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199246};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        338..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        530..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        872..890
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        910..936
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        973..993
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1005..1028
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1038..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1084 AA;  115195 MW;  B48427331319FCBF CRC64;
     MAMNPSRPFI ERPVATSLLM LAILLAGLLA YRLLPLSALP EVDYPTIQVT TLYPGASPDV
     ISTTVTAPLE RQFGQMPGLG QMTSSSSGGA SVITLRFSLG LSLDVAEQEV QAAINAGSNL
     LPSDLPMPPV YSKVNPADAP VMTIAVTSPS LPVIKVHDLV ENRLAPKLSQ VDGVGLVSIA
     GGRRPAVRIQ ANPSTLAALG LSLDDVRSAI ASANVNQAKG SFDGAQRAST IDANDQLRSA
     AEYQNLIIAW KNGNPLRLSD VAQIVDDAEN LRLAAWADTT PGVILNVQRQ PGANVIQTVD
     RVKALLPKLQ GTLPASVDVQ ILADRTTTIR ASVDDTEIEL LLAIALVVAV IFLFLRSGSA
     TLIPSVAVPL SLVGTFGVMY LAGFSINNLT LMALTISTGF VVDDAIVMIE NIARYVEEGD
     SPMEAAFKGS RQIGFTIISL TVSLIAVLIP LLFMGDVVGR LFHEFAITLA VAILISAFVS
     LTLTPMMSAR LLKPETEQKH SRLGTWFGEK FEAMIQGYGR ALDWVLDRPV LTLLGFAATL
     ALTALLYVVV PKGFFPVQDT GLVQVITEAT QSTSFDAMSE RQQRLAEVFL KDPDVDHIAS
     FIGVDGANAS LNTGRMQITL KPFAQRHASA TEVIARLGDL NRQVPGITAY MQPVQDLTIE
     DRVSKTQYQF LLSSPDSTDL QKANDALLAR LKQLPQLADV ASDLQNQGLQ AWVQIDREAA
     GRLGVTVSSI DTALYNAFGQ RLISTIYTQA SQYRVVLEAA SEFRSGPRAL EGLYVPGSTT
     TTSATGTAAT TTVQVPLSSV AQIVERPAAL AINHVAQFPA ATISFNLPPG VALGDAVQAI
     KAEQAKLDLP ISVETSFQGA AEAFSNSLSS TLFLILAAVV TMYIVLGVLY ESYIHPVTIL
     STLPSAGVGA LLALLIGGLD LGIIAIIGIV LLIGIVKKNA IMMIDFALEA EREQGLDPRA
     AIHQASLLRF RPILMTTMAA LLGALPLMLG TGVGHELRHP LGVTMVGGLI VSQLLTLFTT
     PVIYLGFARM AQRWRERRGV KRETRAAAQH RGPDAPEIAD PAAPLAPAGP SLLRQPGDDG
     GAPR
//