ID   A0A1I6LHV4_9GAMM        Unreviewed;      1066 AA.
AC   A0A1I6LHV4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SFS02953.1};
GN   ORFNames=SAMN05216570_1668 {ECO:0000313|EMBL:SFS02953.1};
OS   Dyella sp. OK004.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Dyella.
OX   NCBI_TaxID=1855292 {ECO:0000313|EMBL:SFS02953.1, ECO:0000313|Proteomes:UP000198834};
RN   [1] {ECO:0000313|EMBL:SFS02953.1, ECO:0000313|Proteomes:UP000198834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK004 {ECO:0000313|EMBL:SFS02953.1,
RC   ECO:0000313|Proteomes:UP000198834};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR   EMBL; FOZI01000002; SFS02953.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6LHV4; -.
DR   STRING; 1855292.SAMN05216570_1668; -.
DR   OrthoDB; 9758757at2; -.
DR   Proteomes; UP000198834; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF12; CATION EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198834};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        495..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        550..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        890..909
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        916..936
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        942..970
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        991..1013
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1019..1046
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1066 AA;  115706 MW;  873F160D994F4CB8 CRC64;
     MLRGIVAFAL TRWSIVIMAL ASFVVAGLVA YAKLNIEAYP NPAPVILEIT AQSPGLSAEE
     MERSYTRPME VGLATTPGVD NIRSTSFYGL SFVRVTFKYG VDYYQAYTQA ALNLQQNVSL
     PGGVQPQIQA SSLVGEILRY QLVGPPHYGL TNLRTLQDWV VTRRLLSVPG VAQVVTWGGT
     TKEYDVNADL SKLEGYGVTL PQLIAAIGNA NTNVGGRTIN IGQQSVNIRG VGLIKDIGDV
     GNIVLSQNNG TPVLVKDVAK ISIGNVPRLG KAGRDDQNDV VTGIVVMNRT LQTNEVLARV
     KAEVAKLNSD GTLPAGVKLA PIYDRSTLVN VTTHTVLHNL LFGCLLVFFI QWIFLGDLRS
     AIIVSANIPV ALFFSIIILV LLGDSANLLS VGAVDFGIIV DSAVILIENI FRNFQKNKEE
     RQELLHEQAQ SEFAMYAKGR AAHGWTERMR LLFISTTQVD RAVLFSSAIT VAAFIPLFTM
     QGVEGQIFNP MARTYAYALT GALIATFTVT PVLASLLLPK HIKETETLFV RSIRRVYSPV
     LHWALQRRKL TVLIGVGFLL LAGLLLPRIG TEFLPALEEG NLWIRATLPA TISLEAGMGK
     VNRMRQIIKT HAEVITVVSQ HGRPDDGSDA SGFYNAELFV PLKPISEWPR GETKDKLVKK
     LQQEFSNEFP GIEFNFSQYI QDNIEEGLSG VKGANSVKIV GPELPILEKL ADQVLHEMRQ
     VKGVEDLDAF HVLGQPNLNI TIDRARAARY GLNTGDINSA VQAAAGGTQA TTVLEGDRQF
     SLVVRLAPAY RSDLQAIGNI KVGYATPGGA TAYVPLRELA SITLDTGASY IYHERNERFI
     PVKFSVRGRD LGGTVAEAQQ RIAQHVTLPN GYHLVWAGEF EDMQQAKDRL AIVLPIAIGL
     ILALLFTLFN SFRDSLLTLA AIPFSIAGGI IALYLSGLNL SVSAAIGFVS LFGVSVMNGI
     LVITYFNHLV FEGKSPLEAM YLAAEQRMRP MLMTALSACI GLLPAALSTG IGSQVQRPLA
     TVVVGGMLLG PIMLLIVAPA LQVLVVEWSQ GRKHRRAHRP TEAGGL
//