ID   A0A1I6MHM6_9BACT        Unreviewed;       309 AA.
AC   A0A1I6MHM6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   ORFNames=SAMN05421771_2652 {ECO:0000313|EMBL:SFS15121.1};
OS   Granulicella pectinivorans.
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Granulicella.
OX   NCBI_TaxID=474950 {ECO:0000313|EMBL:SFS15121.1, ECO:0000313|Proteomes:UP000199024};
RN   [1] {ECO:0000313|EMBL:SFS15121.1, ECO:0000313|Proteomes:UP000199024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21001 {ECO:0000313|EMBL:SFS15121.1,
RC   ECO:0000313|Proteomes:UP000199024};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; FOZL01000001; SFS15121.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6MHM6; -.
DR   STRING; 474950.SAMN05421771_2652; -.
DR   OrthoDB; 9795084at2; -.
DR   Proteomes; UP000199024; Unassembled WGS sequence.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   NCBIfam; TIGR02772; Ku_bact; 1.
DR   PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01875}; Reference proteome {ECO:0000313|Proteomes:UP000199024}.
FT   DOMAIN          65..199
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
SQ   SEQUENCE   309 AA;  34110 MW;  0A05A92647D7EAE7 CRC64;
     MALRPYWTGQ IQISLVQFGV KLYVATEAKS EIHFHQISRA TGERVRHQKV LASAADTHDD
     HAGPDAVVEK DEIVKGYEYS KGEYVTIEPK ELEQLRVPSK HTMEISQFVD ASEIDPEFYE
     KPYFVVPEND AQAQAFAVVR QALKETKKVA LTKIAFAGRE HIVALTPTQD DTLGGMMAYT
     MRYAQELRDP KEYFADVKKA SVDADSLSLA KELIKRKAGR FDPEKFVDGY EVALKELVDA
     KVAHAPVPKD EAPAPARGKV INLMDALRKS VAGDEKATPK KTATKTAAKG IALVKASKPA
     AKTAKRKSA
//