ID   A0A1I6Q816_9FLAO        Unreviewed;      1271 AA.
AC   A0A1I6Q816;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Cu(I)/Ag(I) efflux system membrane protein CusA/SilA {ECO:0000313|EMBL:SFS48616.1};
GN   ORFNames=SAMN04488006_1598 {ECO:0000313|EMBL:SFS48616.1};
OS   Lutibacter maritimus.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Lutibacter.
OX   NCBI_TaxID=593133 {ECO:0000313|EMBL:SFS48616.1, ECO:0000313|Proteomes:UP000199312};
RN   [1] {ECO:0000313|Proteomes:UP000199312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24450 {ECO:0000313|Proteomes:UP000199312};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOZP01000003; SFS48616.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6Q816; -.
DR   STRING; 593133.SAMN04488006_1598; -.
DR   OrthoDB; 9758757at2; -.
DR   Proteomes; UP000199312; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 3.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199312};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        366..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        504..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        538..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        586..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        616..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        649..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1080..1097
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1109..1127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1147..1167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1232..1261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1271 AA;  140320 MW;  87D97EDC856A4736 CRC64;
     MLHKIIKYFL ENKLVTALLL LVFIGWGIVT SPFNWNVAFL PKDPVPVDAI PDLGENQQIV
     FTEWPGRSPQ DIEDQITYPL TTSLLGIPNV KSIRSSSMFG ISSIYIIFEE KVDFYWSRSR
     VLEKLNSLPS NLLPEGINPG LGPDATALGQ VYWYTIEGRD PDGNVTGGWD LQELRSAQDY
     YVKYALNAVS GVSEVASVGG YVREYQVDVN PDALKAYNIG IDMVMMAVKN SNRDIGAKTI
     EINKAEYFIR GLGYIKSTKD LENTVVQVTN NKPILIKDIA TVNLGPATRR GVLDKGGAEV
     VGGVVVARYG SNPLEVINNV KAKIKEFAPG LPKKTLADGT ISQLTIVPFY DRTQLIHETI
     GTLETALSHE ILISIIVVLV LLFNLRASII ISSLLPVGVL MTFIVMRYAG VDANVVALSG
     IAIAIGVMVD IGIVFVENII RHLEMPENIG AKGKALLQVI YRGTTEVASA ITTALATTVV
     SFVPVFAMQS AEGKLFIPLA FTKTFALLGA FVLGIVVLPS LAHVIFGINF NNKRVKRIWG
     IVLIVAGLIM AITYLTWLPL VLCILGAQTL FEHQIPAKFR KHSNKINVGL MLFIATFFLA
     QAWMPLGPQN SVFANYLFVI IIMGLILGAL FSIVHFYETI LKWCLDNKAT FFLIPVFTLF
     LGVLSWIGFN NTFSFVRNGT EKIGWNISET TVWKTASNTF PGMGSEFMPS LNEGSFLLMP
     TTMPHAGIEE SKNTLQKLDI LVANIPEVEN AVGKLGRVES AIDPAPISMF ENIINYKSEF
     IVNDEGKPKR FQVDNDNNFV LKDGTAISNE DALKQGITET NLVLDANGEY YRNWRSHIKN
     SDDIWNEIVK VTNIPGVTSA PKLQPIETRL VMLQTGMRAP MGIKVYGPDL KTIQDVGLTL
     ESILKEVPSV KSNAVFADRI VGKPYLVIDI NRDAIARYGL SIEKTQQILE TAIGGMKTTT
     TVEGRERYPV RVRYPRELRD DPEKIKKIVV PTPTGVQVPL GELVTINFIR GPQMIKSEDT
     FLVGYVLFDK KENYAEVDVV NDAQALIDSK IADGSLVVPK GVSFKFSGSY ENQVRAVKRL
     SIVIPISLVV IFLLLYFQFK TVIASSIHFS GVFVAFAGGF IMLWLYGQDW FLNFSVSGVN
     MRDLFQIHTI NLSVAVWVGF IALFGIATDD GVIMGTYIHQ VFEEKKPTTV SEVRAAVLEA
     GKKRVRPAMM TAATTIIVLL PVLSSTGKGS DIMIPMAIPT FGGMIIQIMT MFVVPVLQAY
     WRESVIKKNN K
//