ID A0A1I6QCU7_9RHOB Unreviewed; 962 AA.
AC A0A1I6QCU7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Multisubunit potassium/proton antiporter, PhaA subunit /multisubunit potassium/proton antiporter, PhaB subunit {ECO:0000313|EMBL:SFS50155.1};
GN ORFNames=SAMN04488040_0649 {ECO:0000313|EMBL:SFS50155.1};
OS Sulfitobacter marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Sulfitobacter.
OX NCBI_TaxID=394264 {ECO:0000313|EMBL:SFS50155.1, ECO:0000313|Proteomes:UP000199239};
RN [1] {ECO:0000313|Proteomes:UP000199239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23422 {ECO:0000313|Proteomes:UP000199239};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur
CC (Fe-S) centers, to quinones in the respiratory chain. The immediate
CC electron acceptor for the enzyme in this species is believed to be
CC ubiquinone. Couples the redox reaction to proton translocation (for
CC every two electrons transferred, four hydrogen ions are translocated
CC across the cytoplasmic membrane), and thus conserves the redox energy
CC in a proton gradient. {ECO:0000256|ARBA:ARBA00002378}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; FPAJ01000001; SFS50155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6QCU7; -.
DR STRING; 394264.SAMN04488040_0649; -.
DR Proteomes; UP000199239; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199239};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..119
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 135..412
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 619..682
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 693..773
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 803..925
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 962 AA; 102703 MW; A32DD16E490BB9FE CRC64;
MAPLADNCGM SLFLIIALPF LGALLPGLMI QAGRQSCFIM TFLVTASALI GLATHAPAVL
AGDVVTAQLN WLPSLGLNVN LFLDPLGLMF AGLILGIGLL IITYARFYLS RDDNMGEFYT
YLLLFQGAMV GIVLSDNILM LLVFWELTSL SSFLLIGFWK HTADGRQGAR MALTVTGMGG
LALIGGMLLL GQIAGSYDLT TILENRELIQ ASPLYVPALI LILVGCFTKS AQFPFHFWLP
HAMAAPTPVS AYLHSATMVK AGLFLMARLW PVLSGTDLWV ILVCSAGLIT MVLGAVIALF
KDDLKALLAF STVSHLGLIT FLLGTGTAFG AMAAVFHILN HASFKAALFM TAGIVDHAVH
TRDMKRLGGL RRLMPLTFAV ATIAALSMAG IPLLNGFLSK EMMLEEAYHT TLFGSPYLVA
VVATLGALFS AGYSFRFVAH TFLGPVRDDY PDTPHDPQVG LLLPPALLII PVIAIGVAPF
LAEPFVKIVT QAVIGNAAAL PDAHLKIWHG LVPALWMSVI AVVGGLILLA AFAPLARLWA
ATPRPEAKDI FDRIIAAAVS LAYVFAERLH NSSFTRYAAI FTATVIAIGA HAWFTGVNAA
PTRDMLAITP VGFAGWLMLI LATVFLVTVH RNRLATLILM GVIGLMVSVG FNYFSAPDLA
LTQISVEVVT IVLLLLALNF LPNATPVEST AGQRTRDIIL ALAGGIAAMG LTYAMLMSDF
PITSISEYHL ANSYKGGGGT NVVNVILVDF RGFDTFGEII VLGIAALVIY ALTEALLAGP
VRARLLNRGY EEARAGDAHP LMMVVLTRVL MPLVLMVGVF IFLRGHNEPG GGFIAGLVVA
IAVLMQYMAS GFSWAERRQR YPYHGIIGAG VLCAGLTGIG AWFAGAPFLS SAFGYFRIPP
MEKFELATAM GFDLGVFLAV VGAVMLSLES FSRLGRRAGI EESDYAMDID PSRIETLTGG
ES
//
