ID   A0A1I6S275_9CAUL        Unreviewed;       773 AA.
AC   A0A1I6S275;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=SAMN05192570_2111 {ECO:0000313|EMBL:SFS71047.1};
OS   Brevundimonas viscosa.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Brevundimonas.
OX   NCBI_TaxID=871741 {ECO:0000313|EMBL:SFS71047.1, ECO:0000313|Proteomes:UP000198788};
RN   [1] {ECO:0000313|Proteomes:UP000198788}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.10683 {ECO:0000313|Proteomes:UP000198788};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; FOZV01000004; SFS71047.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6S275; -.
DR   STRING; 871741.SAMN05192570_2111; -.
DR   OrthoDB; 9806690at2; -.
DR   Proteomes; UP000198788; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          27..306
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          307..573
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         48..55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   773 AA;  86218 MW;  5F9862254988CAAD CRC64;
     MTDSAPPRIS DLARARPPAG ALPDYLSGLN PEQREAVETT EGPVLVLAGA GTGKTRVLTT
     RLAHILATGK ARPWELLAVT FTNKAAREMR ERITHLIGPS AEGLRWLGTF HSVAAQILRR
     HAELVGLKST FTILDTDDQE RVCKQLIEAA NLDAKRWTPR SLSGLIDHWK NRGWTPEKLP
     PSEDFANGKG QTLYAAYQAR LASLNACDFG DLLLHNITIL SQHADIAEEY RRRFRYILVD
     EYQDTNVAQY LWLRLLTSST GNVCCVGDDD QSIYGWRGAE VDNILRFERD FPGAKVIRLE
     RNYRSTHHIL GAASGLISAN RGRLGKTLWT EETSGDKVRV RGVWDGEAEA RLIADEIETA
     KKSGLHYRDM AVLVRASFQM RAFEERFVML AIPYTVIGGP RFFERAEIRD AHAYLRLILS
     EDDDLAFERI VNVPKRGIGD TSVQKILTIA RENGVSAMQA VRALLGSDEL QARTRTALSN
     FVRDLDRWRA RAPEIPHWEL TEMVLEESGY TDMQKADRTS GQTRLDNLKE LVQSMQAFDG
     LTAYLEHVSL VMDLDRGDSA DSVQIMTLHG AKGLEFPLVF LPGWEEGVFP SQRSIDEKGE
     KGLEEERRLA YVGVTRAKQD ARISFAANRL VYGRWTSQLP SRFVDELPID HVEAESDTGY
     YGASAGMKEA KSRWDEAPSF GSGYSSPGWK RAQSATAARA PADRPARHTL IEGDGRLIAT
     ADPKAGSGWA KGDRVFHQKF GYGHVRAIEG NKLVVAFDKA GEKKVIDTFV EKA
//