ID A0A1I6TLC6_9PSEU Unreviewed; 2153 AA.
AC A0A1I6TLC6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D {ECO:0000313|EMBL:SFS90053.1};
GN ORFNames=SAMN05660874_04060 {ECO:0000313|EMBL:SFS90053.1};
OS Saccharopolyspora flava.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=95161 {ECO:0000313|EMBL:SFS90053.1, ECO:0000313|Proteomes:UP000198852};
RN [1] {ECO:0000313|EMBL:SFS90053.1, ECO:0000313|Proteomes:UP000198852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44771 {ECO:0000313|EMBL:SFS90053.1,
RC ECO:0000313|Proteomes:UP000198852};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; FOZX01000007; SFS90053.1; -; Genomic_DNA.
DR STRING; 95161.SAMN05660874_04060; -.
DR Proteomes; UP000198852; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..80
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 92..512
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1707..1784
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1799..1874
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2153 AA; 230029 MW; 11DFBA808E76B6BD CRC64;
MSDAMSETEI RRWLTDRVAA TAGLQRVDPD RPLHEFGLSS RDAVALAAEL GERLGRRLSP
TLVWQNPTIT ALAARLSGGE EVDIPRPRVR RDEPIAIVGL GCRLPGGVNS PERFWRLLDD
GADAIRELPE GRWADFAPRE DWHDLPARGG FLDDVAGFDA AFFGITPVEA AAMDPQQRLL
LEVTWQALEH AGIPPQELRG SRTGVFVGLS STEYGSLTMS ELDTVDAWTG TGAAAAIAAN
RLSYLLDLRG PSLTTDSACS SSLVAVHQAA ASLRDGESDL AVVGGVNLML SPGITANFHR
AGVLSAEGRC APFSASADGI VRGEGCGVVL LKRLSDARRD GDRVLSLVLG TATNSDGRSN
GLVAPNPEAQ RALLRDAYAA ADLDPAVVDY VEAHGTGTPL GDPIEAEALG EVLGESRAER
RPLLVGSVKS NLGHLEGAAG LVGLIKVVLA MRHGRIPASL HAAEPSPHID FDAARLRIAG
TGAAWPRYSG IARAGVSAFG FGGTNAHVVL EEWPEPEPEP EPDEAVPHVF ALSARSESAL
RRRAADLADD LGETPLGDVA AALVTRRDHH PHRAAVVAGD REELAEKLRG LAGDGVHVGE
TAGTGLVFVF SGYGSQWKGM GGRLLETEPR FRSVVDDLEP MFAQETGFSL REVLRGDAEE
PDLAARQQVL FAVQIALAAT WRAHGVEPDA IVGHSMGEVA AAVVAGALPF ADGLRVMVTR
SRLLAGLDAG GAGRMAAVEL SETEFAELAA DHPDVSIAVH TSPTQCTVTG DAAQVEALVA
RVEARGRMAR ALDVGGAGHS AAVDPILDEF RARLGELTPA KPEIRCYSSV LDDPTRVPEF
DEHYWAANLR RPVRFTQALA AAMADGHRTF LEISPHPLAR FAVEGTAAAV GADRVTALPT
LLRDADDQRS LLAAMAGLHV AGHETALRTR YPRGPVVDLP GPAWEHQRHW VRPRRRTTSG
EHPVLGTHVE VPDADLHVWR GEVGTDAQPW LADHVVQGVP VLPATGYLDA ALSAAAVAFG
PDRPVRVRDL ELRQPLPLAA GTTVHTSLRT TGDDTAQVAV HARSAAGRWV RHAVATVRAE
HPGRPGPEPL GELTGGRPVE VYRELAELGQ HYGPAFRGLR TARAGNDRAS AGIALPAAAP
RSRHHVLHPA LADSCLHALA AAAAERVAED PGLHLPMSLG SVRVFGDPAE GVRCDAVLDP
ADEHGDGLVG TVQLVDGSGR VLVEMAEVYL RRLRAPMPVP LADKTFELRW HRADCAPAER
PRRRWLLLAD GPAAPEVGRA AADLVEAGEE PVVLSTSDIG ELGRWKAGCD GVVLVTGAPE
RYDEPGNARW LLRTAVEAAN GLTAADGRLW LVTRDSVAVG DDPGAAGLAF LRGLVRVLAF
EHPELRVTHL DLDSASPGAL AAELAASAAD DEVAWREGAR FAARLERVEI PERPDVPVVR
DGAYVLTGGL GGLGLLVARW LAERGATRIV LCGRSAPSGP ASQVLDELRG RGTQVRVVLG
DIAENGTAEE LIREAGAGGV PVRGVLHAAG VLADATVSTL TEADVERVWR PKVDGARRLH
EATAGLDLDW WLVFSSAAAL LGSPGQTAYA TANAWLDAFV RWRRGRGLPA ATIQWGPWDE
LGGAVGRDNA VLRPLTPGEG LEALEAVLAS GRAATGVTRL DAAATLELFP ELARRPLFAA
LAEETDRTGA EGDGPDVEAL RAAEPAQAHR AILAALVSRI SGLTGLDPAS FDTTAPLTRL
GLDSLMAMRA RTAFERDFGM TVPIPMLLRG ASLEEVAAHV AAELGLQPVE IGGGRQVLEP
REQVERWIAA LWREVLDVEV LDVHDDFHAL GGDEDRAERV HRRITERFPD APGRAELFAR
PTIARMADLL RPWFDTAEPV LALRDRGERA PLFLFHPAGG STGVYRPLVD LLPGDQPCYG
FERFDDARSV EDSAGRYIGL LREIQGSGPY RLAGWSFGGC LAYEVARQLT ELGEPVDLVA
MIDSILPLPA PESQQQDLLL NRYGRFLDYV EQTYATSLGL GVEDLAGLPE DEQIRFVMDR
IADRVPDMGE AVLHHQYTSY VDARIAERYR PRPYPGRVLL LRSSEPHPLT TSLDPRYLRT
DESLGWDEFC SDLRIVRVPG DHVSMIDPPH VSVIADHLEG ELACSIARPP RIG
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