ID   A0A1I6UKP2_9PSEU        Unreviewed;       646 AA.
AC   A0A1I6UKP2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Squalene-hopene/tetraprenyl-beta-curcumene cyclase {ECO:0000313|EMBL:SFT01934.1};
GN   ORFNames=SAMN05660874_05019 {ECO:0000313|EMBL:SFT01934.1};
OS   Saccharopolyspora flava.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=95161 {ECO:0000313|EMBL:SFT01934.1, ECO:0000313|Proteomes:UP000198852};
RN   [1] {ECO:0000313|EMBL:SFT01934.1, ECO:0000313|Proteomes:UP000198852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44771 {ECO:0000313|EMBL:SFT01934.1,
RC   ECO:0000313|Proteomes:UP000198852};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|ARBA:ARBA00006333}.
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DR   EMBL; FOZX01000011; SFT01934.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6UKP2; -.
DR   STRING; 95161.SAMN05660874_05019; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000198852; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   3: Inferred from homology;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          34..313
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          327..642
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  72285 MW;  A344657288E03CAE CRC64;
     MTDQLQQSAR SAATAAEIPS QGAVRADARM AALAARDHLL SLQSPEGWWK GELQTNVTMD
     VEDLLLRQFL GIRTATETEQ AARWIRSQQR EDGTWANFHG GPGDLSTTVE AYTALKLAGD
     DVEAAHMRIT RDWILARGGL EETRVFTRIW LALFGEWSWD DLPAMPPEVV LLPKWCPLNV
     SDWACWARQT VVPLTVVCTL RPRRDLGISV RELRTGRPAS PPRREWSWAY GFHSLDRVLH
     RYHRRPVKSL REHAMRRAAE WIVARQEADG SWGGIQPPWV YSILALHLLG YPMDHPVIAQ
     GLSGMERFLI REQTPDGVVR RLEACQSPVW DTVLGVQALH DAGVPADHPS LRRAADYLLA
     EEIRVKGDWA VQRPDLPAGG GWAFEFDNDG YPDIDDTAEV LLALNRVDHP DPEAVRGAIA
     RGLRWLRGMR SKDGGWAAFD ADNTRQLVRK LPFCDFGEVI DPPSADVTAH VVEALAVLGE
     DDEVLRGGVK WLLANQERDG SWFGRWGANH VYGTGAVVPA LVAAGVDRQH RSLRDAVRWL
     EQHQNADGGW GEDLRSYDDP EWIGRGASTA SQTGWALMAL LAMNRHDSDA VRRGVGYLAR
     SQRADGGWDE PQFTGTGFPG DFYINYHLYR VIFPLTALGR YLRDGE
//