ID   A0A1I6VGI7_9ACTN        Unreviewed;      1121 AA.
AC   A0A1I6VGI7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SFT12767.1};
GN   ORFNames=SAMN05444716_10854 {ECO:0000313|EMBL:SFT12767.1};
OS   Streptomyces harbinensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1176198 {ECO:0000313|EMBL:SFT12767.1, ECO:0000313|Proteomes:UP000198873};
RN   [1] {ECO:0000313|Proteomes:UP000198873}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7047 {ECO:0000313|Proteomes:UP000198873};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FPAB01000008; SFT12767.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6VGI7; -.
DR   STRING; 1176198.SAMN05444716_10854; -.
DR   Proteomes; UP000198873; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198873}.
FT   DOMAIN          6..82
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1039..1114
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1017..1041
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  115219 MW;  D20C6AF7D16B161D CRC64;
     MSEVPEAGGD RLRAAVAEVW RRAVGAEPAG DDDHFFLAGG DSIVAVEAAM SLRSVTGTEV
     ELDLLYEYPE FGRLVAALAG EGGAARTGRP LTPAEERLWA SEQLWPGTAR YHVGAVYRFA
     GRLDVAGLRA ALDGLAAAHP ALRRGFAAPG LAVEADPARV RVPCRWVAAP GVSEAELGAL
     LDREVREPFE LARPPLLRAL VVDRGAAGDV LLLTVHHLVC DGASLTLLEE ELGRRCAGAD
     DAGAPGAPPV VPSGGAVVDG PAALAYWRRR LTGAPQAMAL PADLPRPAVL GTGGAVHRAA
     FAPRALAALR AVAGQERLSP FMTWLAAYAV GLAAVTGDRD LVVAVPASAR EPGGGAEIGM
     FVDTLPLRLT LPPRVTAREV ARRVRRAVAE ALAHRRAPLQ DILAGLRIGA DRSRAPLAQV
     ALTHRMAGEG GLRLAGRWAR RELWPTGTAK YELLWSVVDG AEPELELEYH TELFSPAAAG
     ALHERLIGAA AAAFAAPDAP LPEVVREPSG GGDGPGYEAV HQRFERHAVR RPGAAALVDG
     ALRLTYGELA VRARAVAAGL RAAGLGRGSV VAVVAERGAG SVTGFLGALY AGCGYLPVDP
     GQPAARAVRL LGAADAVLVA RAAVDAVPGA AGGGPVLVLE ELWDRPVGPG APGPAAVTGA
     DVAYVMFTSG STGEPKAVVV PHRAISRLVP DADYLRIGPE DRVAHLSHPA FDAATFEVWG
     ALAAGATLVV GGRDVALAPA RLREFVAGER ISVLWLTATL FHQVVDFAPD ALAPLRVLLA
     GGEQLDARRL AALLARPDRP GRVVNGYGPT ENTTFSTWHD ITPADAAAGT VPIGRPVSGT
     TAHVLDGAGA PVPVGAVGEL VVGGDGLAHG YLGDPAATAA AFVPDPFDPR GGRRLYRTGD
     LVRVLPGGLL AFEGRRDDQV KIRGHRVEPA EVERELCALP GVGRAVVLAR PTEHGAELVA
     WVTPVPGGGA GALDGAALAA ALRERLPDPL VPLVVPLERL PVNASGKTDR AALLAGAGPS
     VASPPEAPPA PEPADPAAGS GDALAGRIAA LWCEVLQVPA VGPGDSFLAL GGHSIMALRL
     LARLDEEFAV TVELVDFFAD PTPAGLTALV RGAGVGDVLA D
//