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Database: UniProt
Entry: A0A1I6X6I2_9RHOB
LinkDB: A0A1I6X6I2_9RHOB
Original site: A0A1I6X6I2_9RHOB 
ID   A0A1I6X6I2_9RHOB        Unreviewed;       697 AA.
AC   A0A1I6X6I2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFT33905.1};
GN   ORFNames=SAMN05216236_10195 {ECO:0000313|EMBL:SFT33905.1};
OS   Sedimentitalea nanhaiensis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Sedimentitalea.
OX   NCBI_TaxID=999627 {ECO:0000313|EMBL:SFT33905.1, ECO:0000313|Proteomes:UP000182466};
RN   [1] {ECO:0000313|EMBL:SFT33905.1, ECO:0000313|Proteomes:UP000182466}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.10959 {ECO:0000313|EMBL:SFT33905.1,
RC   ECO:0000313|Proteomes:UP000182466};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; FPAW01000001; SFT33905.1; -; Genomic_DNA.
DR   RefSeq; WP_027263043.1; NZ_FPAW01000001.1.
DR   STRING; 571166.KI421509_gene3104; -.
DR   BioCyc; GCF_900116455:G1FNT-3225-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000182466; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000182466};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182466}.
FT   DOMAIN      291    467       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      472    566       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      602    687       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   697 AA;  74699 MW;  B40618EF5E056E7B CRC64;
     MTDAIGYERT GDIAILKAQN PPVNALGYDV RVGLMQGIAR AEDEGARAVL IYGDGATYFA
     GADIREFGQK PREPGLPEVC DRIEASPLLV VSAMHGTALG GGLEVALSTH YRIAVPSARV
     GLPEVLLGIL PGAGGTQRLP RVAGVEAALD LITTGRHVPA AEALRLGILD KVEAGEPREI
     GLAYVQQLLD ADAPRRPVSE MPSPAPVDFD AVYDTVLKKG RGQLSPATAV RAVQAATELP
     FRQGIARERE LFMELMNTDQ RLGLIHAFFS ERAVSKLPEL KGVAPRDLNA IGVIGGGTMG
     AGIATAALLA GLSVTMLEMS PQAAEAAKSR IAGNLQGALK RGKISQEQFE TLTEQALTLA
     TDYEALKDAD LVIEAVFEEM DVKKKVFTQL DAVCKPGAVL ATNTSYLDVN DIAAITKRPQ
     DVIGLHFFSP AHVMKLLEVV VADQTAADVV ATGFALGKRL GKISVRAGVC DGFIGNRILS
     TYRTCADHMI LDGASPYQID KALEAFGFAM GPFAVADLAG LDIGWAVRKR KRAEGIDPRA
     RDSSYADKLC EDGHFGQKTG KGYYDYAAGP KSRVPNPDVM PLIEAERAAQ GIAPREFTDE
     EIVRRYMAAM VNEAAKVVGE GIARRPLDVD MTLLFGYGFP RYNGGPLKWA DIQGLEGLLE
     DIKSYAKEDA YFWQPAPLLE KLVAEGRNFD DLNKEAS
//
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