ID   A0A1I6YI21_9FLAO        Unreviewed;      1010 AA.
AC   A0A1I6YI21;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SAMN05216474_0905 {ECO:0000313|EMBL:SFT49977.1};
OS   Lishizhenia tianjinensis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Crocinitomicaceae; Lishizhenia.
OX   NCBI_TaxID=477690 {ECO:0000313|EMBL:SFT49977.1, ECO:0000313|Proteomes:UP000236454};
RN   [1] {ECO:0000313|EMBL:SFT49977.1, ECO:0000313|Proteomes:UP000236454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.7005 {ECO:0000313|EMBL:SFT49977.1,
RC   ECO:0000313|Proteomes:UP000236454};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; FPAS01000001; SFT49977.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I6YI21; -.
DR   STRING; 477690.SAMN05216474_0905; -.
DR   Proteomes; UP000236454; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236454};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..96
FT                   /note="PHP"
FT                   /evidence="ECO:0000259|Pfam:PF02811"
FT   DOMAIN          248..480
FT                   /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT                   /evidence="ECO:0000259|Pfam:PF07733"
FT   DOMAIN          486..655
FT                   /note="DNA polymerase III alpha subunit finger"
FT                   /evidence="ECO:0000259|Pfam:PF17657"
FT   DOMAIN          727..811
FT                   /note="DNA polymerase helix-hairpin-helix motif"
FT                   /evidence="ECO:0000259|Pfam:PF14579"
SQ   SEQUENCE   1010 AA;  116929 MW;  3C1EF9CE85BCCDA0 CRC64;
     MFNTHSKYSL RYGLKSPESI VDFYKEAGYS CAFITDINTS TAALSLSRYA QEQDFNAAIG
     IDIRNGMEQC YVILATNNRG FHELNTFVSE HLQKNLEFPA LAPYLSNCVT IYPWQKAPQK
     LGPNEWIGVS KKGLQDYNWK KLQHTDKTLI LQPMSFANKR DFNAHRLLRA IENNCLLSAL
     PATEQADADD LFISKEELYQ SFEEYPEIIA NTEEIAQSCS IHFKFGDDVE SQNLKSYTGS
     CQEDYELVKK LCAKGIKERY KEITPAITTR VEKEIEIIRE KEYLSYFLIS WDIINYARNK
     GYFYVGRGSG ANSIVAYLLK ITDVDPLELD LYFERFINLY RKTPPDFDID FSWKDRDDVT
     HYIFERFPNA ALLCTYNTFQ YKATVRELGK VFGLPKADID QLSNGKALHQ VDEMGRLVLK
     YSKFIEGLPS HLSIHAGGII ISERPTSWYS ACFMPPKGFP TTQFSMLEAE DVGLYKFDIL
     SQRGLGKIKD CIDIIHQNQP HNPPHDIRDV AHFKEDPKIK EMLMKAQALG CFYVESPAMR
     MLMIKLEVKS YLELVAASSI IRPGVAQSGM MREYILRHKN PERRKEAHPV MLQIMPETYG
     IMVYQEDVIK VAHHFGGLTL GEADVLRRGM SGKYRSREEF LQVKDKFFEN CKHKGYAEKD
     VTEIWRQIES FAGYAFAKGH SASYAVESFQ SLYLKAYYPL EYMLATINNF GGYYRTETYV
     HEARMLGANI EAPSINKGAW ESSIQGDTLY LGFNLVHACE HKVIHKIMQE RKRKNFENFD
     DLINRVHIPL EQLNLLIRIG ALRDFQEGKK ELLWRSHFYH NAHKEKHREP VLFYPPQKQF
     TLPQLQEAPY EANFEQMELI GFPLVNPFEL SKEKIPPHVT AEDLPRHLGQ SVISFGYLIT
     LKRSKTVNKD YMYFGTFMDI HGEMLDTVHF PFVGKKYPFQ GKGIYKFQGI VSEEFGYHTI
     EVNRMRKVAF LDDPRYTEIE DPKEGKVVTD NFTTAIDFKK KRKSPENQLQ
//