ID A0A1I6ZQA7_9FIRM Unreviewed; 503 AA.
AC A0A1I6ZQA7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02910301_0036 {ECO:0000313|EMBL:SFT64810.1};
OS Lachnospiraceae bacterium XBD2001.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1520820 {ECO:0000313|EMBL:SFT64810.1, ECO:0000313|Proteomes:UP000199425};
RN [1] {ECO:0000313|EMBL:SFT64810.1, ECO:0000313|Proteomes:UP000199425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XBD2001 {ECO:0000313|EMBL:SFT64810.1,
RC ECO:0000313|Proteomes:UP000199425};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
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DR EMBL; FPAN01000012; SFT64810.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I6ZQA7; -.
DR STRING; 1520820.SAMN02910301_0036; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000199425; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000199425};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 6..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 280..498
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 503 AA; 55047 MW; 6294AC5C5E2D01AF CRC64;
MNSLGKVVLV GAGPGDIGLM TIRGQEYLEK ADCIIYDRLL NPRLLSIASA NCEKIFVGKA
NHLHTVPQDK INELLYEKAC EYKLVVRLKG GDPYVFGRGS EEALYLIDKG VQVDVVPGVS
SSIAALAAAG IPVTHRGVSK GFQVITAHSK EDALADIDYS KLTDETVTYI FLMGLSHVGE
IARGLIAAGR DAGTKVAVIS NGTTNHQKKV VATLNDIDEA VAVALIDSPA IIVVGEVAKL
EKELNFFEQR PLFGKKVFLP VIKGFDYTIG NPRKSFFENE LESKLIEFGA EVITACSGVI
KPIECDLKFL TALKENAFIV FTSANGVKAF FWNLFEVNNL DSRAISNVKF ACIGQKTAST
LKEFGFNSDI ISEKQTGEDL ALALNGRLDS SSETYWFCQK NTSELFEKNI DSKIKLNKIV
CYENKQLEYD NSEDMREKVS TCEIAIFTSG SNATFAIEQF GNNVPKKIIS IGPACSKTII
NLGYEVYKEA EISSYDGIME LLL
//
