ID   A0A1I7A028_9ACTN        Unreviewed;       501 AA.
AC   A0A1I7A028;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE            EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN   ORFNames=SAMN05660657_02367 {ECO:0000313|EMBL:SFT68247.1};
OS   Geodermatophilus amargosae.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1296565 {ECO:0000313|EMBL:SFT68247.1, ECO:0000313|Proteomes:UP000199546};
RN   [1] {ECO:0000313|Proteomes:UP000199546}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 46136 {ECO:0000313|Proteomes:UP000199546};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC         methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00000086};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FPBA01000007; SFT68247.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7A028; -.
DR   STRING; 1296565.SAMN05660657_02367; -.
DR   Proteomes; UP000199546; Unassembled WGS sequence.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR   Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR   Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR035451; Ada-like_dom_sf.
DR   InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR   InterPro; IPR010316; AlkA_N.
DR   InterPro; IPR037046; AlkA_N_sf.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR   PANTHER; PTHR43003:SF13; DNA-3-METHYLADENINE GLYCOSYLASE 2; 1.
DR   Pfam; PF02805; Ada_Zn_binding; 1.
DR   Pfam; PF06029; AlkA_N; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM01009; AlkA_N; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF55945; TATA-box binding protein-like; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          96..194
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000259|PROSITE:PS01124"
SQ   SEQUENCE   501 AA;  52728 MW;  F9A9C9FD412573C8 CRC64;
     MRCHARCVLS SIDAERCYRA VASRDARFDG WFFTAVRTTG IYCRPSCPAR TPAAVNVSFF
     GSAAGAQAAG YRACRRCRPD AVPGSPEWDV RADVVARAMR LIADGEVERS GVPGLAARLG
     YSERQVHRLL VGELGVGPLA VARAQRAQTA RVLVETTDLP MADVAFAAGF ASIRQFNDTV
     REVFACTPSE LRHCRPGSDG GTPGWLTLRL AARAPFDAAE VLHFLGAHAV PGLEEWDGTT
     FSRVLDLPAG PGVVRLSPAP DGGPAVTARL LLTDLRDLRA AVPRCRRLLD LDADPTAVDE
     VLGVDPALAP LVAGAPGRRV PASPDGPESA VRAVLGQQVS VAGARTLTAR VLTLAGTPLA
     EPVGTLTHAF PRPEALADAD LSAVGLTGAR RRTLGGLAAA MAEGRVVLDP GCDREAVARD
     LLALPGIGPW TASLVVMRGL GDPDVWLPGD LALRRALASL GSSDAEAATR WRPWRSYAAM
     HLWALAAPTL FTRSPADRSA S
//