ID A0A1I7A0G6_9GAMM Unreviewed; 568 AA.
AC A0A1I7A0G6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Potassium/proton antiporter, CPA1 family (TC 2.A.36) {ECO:0000313|EMBL:SFT68392.1};
GN ORFNames=SAMN04487956_11465 {ECO:0000313|EMBL:SFT68392.1};
OS Halomonas saccharevitans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=416872 {ECO:0000313|EMBL:SFT68392.1, ECO:0000313|Proteomes:UP000199594};
RN [1] {ECO:0000313|EMBL:SFT68392.1, ECO:0000313|Proteomes:UP000199594}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6493 {ECO:0000313|EMBL:SFT68392.1,
RC ECO:0000313|Proteomes:UP000199594};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FPAQ01000014; SFT68392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7A0G6; -.
DR OrthoDB; 9810759at2; -.
DR Proteomes; UP000199594; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022538};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022449}.
FT TRANSMEM 56..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..483
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 568 AA; 61106 MW; C8F241989E8E9952 CRC64;
MDSINSLFLL SGFLLALSIL ASRLSSMAGV PLLLIFLGLG MLAGEEGLLG IQFDDYSLAF
SIGHLALAMI LLDGGLRTRL KTFRVGFRPA LSLATFGVFI TGGLVGVFAM WVFDLSLVQG
LLVGAIVGST DAAAVFSMLS GRGVNLNERV GATLEIESGT NDPMAIFLTL MLVEVLVGDI
GGVGETLLFL VQQFGLGILI GLGVGWLSAR LLSWLDLAPG LYSLLALGLG FCVFGLTSAL
GGSGFLAIYL AGLMIGNRPG RHLAFILPVH DGLAWLSQIG LFLVLGLLVT PSEMMDFALP
ALLVALALIF VARPLAVLIV VKPFFKFRWR EIGFIAWVGL RGAVPIVLAI FPVIGGVENA
SLYFNVAFAV VLLSLLIQGG SLPWMARRMK VELPPTVTPN RRGSLGILPE NDYEMFVYEV
ENADLEDVPI RLLRFPSGAL ISALFREHAM LHPKGSTRLR LGDVICVIGR TDDLPGLNRL
FNGDAKLKRE RAFFGTFTFD GDAFMRDIAD AYGLTLSPGE QDMTLAEFVS LRVGGHPVVG
DDVDWHGIHW VVSAMEGNRV TRVGLRLY
//
