ID A0A1I7AME4_9FLAO Unreviewed; 1453 AA.
AC A0A1I7AME4;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN05216474_2225 {ECO:0000313|EMBL:SFT76045.1};
OS Lishizhenia tianjinensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Crocinitomicaceae; Lishizhenia.
OX NCBI_TaxID=477690 {ECO:0000313|EMBL:SFT76045.1, ECO:0000313|Proteomes:UP000236454};
RN [1] {ECO:0000313|EMBL:SFT76045.1, ECO:0000313|Proteomes:UP000236454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7005 {ECO:0000313|EMBL:SFT76045.1,
RC ECO:0000313|Proteomes:UP000236454};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; FPAS01000003; SFT76045.1; -; Genomic_DNA.
DR STRING; 477690.SAMN05216474_2225; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000236454; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000236454};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..192
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 257..345
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1453 AA; 165504 MW; 4AEC742977AB7DC3 CRC64;
MYIIFDTETT GLPRNWNAPI TDTDNWPRCI QIAWQLHDDM GRLIEAKDYL VKPDGFDIPY
DAERIHGIST ELAMEQGEDL DMVLKEFNVA LSKAKFVVGQ NVGFDVNIMG CEFYRQSVDS
PMAEMPVLDT CTEITANLCK IPGGRGGKFK LPTLTELHEF LFQQPFAEAH NATADVEATT
RCFFELIRRE VFTEEELQVE RNYFDNFITV NPNMIEGVGL THLNLKEESA KLKTDTSSVS
KAEIKEGLEK LEGVNFTHLH NHSQFSILQS TTDIKGLIAK AASLDMPAVA LTDTGNMMAA
FHFEKYITEH NNKIKAERAA AEEKGEPYTK TELMPIIGCE FNVCRDHLDK SNKDNGYQIV
LLAKNKRGYH NLAKMASIAF TDGMYYVPRI DKNVVEKYKG DIICLTGNLY GEVPSKILNV
GEAQAEEALV WWKEQFQDDF YIELMRHGQE DEDRVNETLL KFAETHDVKV VATNNTFYLE
KEDAKSHDIL LCVKDGELRD TPKGRGRGFR FGLDNDEYYF KTADEMKEVF ADIPEAIINT
NEIVAKIEHY HLAMDVLLPA FDIPEEFLDE RDKEDGGKRG ENNYLRHLTY EGAKQRYEEI
TDEIRERLDF ELSIIAKTGY PGYFLIVQDF CNASREMGVS VGPGRGSAAG SAVAYCTGIT
NVDPIKYDLL FERFLNPDRV SMPDIDIDFD DEGRGRVIQW VIDKYGANQV AQIITYGTMA
AKSAVRDTSR VMDLSLFDAD RIAKLIPDLS LAKMFNLTDE QLAEKLKNNQ EDIQRVMEFR
ALAEGNDLTG EVIQQARKLE GTIRNTGIHA CGVIITPSDI TDYVPVARAK DSELYCTQYD
NSVAEEAGLL KMDFLGLKTL TLIKDAIRHV KDRHGIDLVA DDFPLDDEKT YELFQRGETV
GVFQYESPGM QKYMKDLKPT VFADLIAMNA LYRPGPLEYI PSFIRRKHGE EEIVYDLDAC
KEYLEETYGI TVYQEQVMLL SQSLAGFTKG EADTLRKAMG KKKLDLLAKL KPKFLDQGNE
RGHDRDKLDK IWRDWEAFAS YAFNKSHSTC YAWVAYQTAY LKAHYPAEYM ASVLSNNMND
LKQVTFFMEE CKRMGVEVLG PDINESDYKF TVNKQGAIRF GLGAIKGVGS GPVNAIKTER
EENGPFRDIF DLTKRINLRL CNKKAFESLA LAGGFDSFKN IHRAQYFIED NGKTFLETAI
KFGANYQENE NSAQASLFGE ASGTEIPAPQ VPHAEEWTSM YKLNREREVV GIFISGHPLD
DYRLDIESFC NGNVGMLNEM EKHANKEVSI ACIITECEER RTKRNDPFGT LLIEDYNDSH
KLFLWREDFL KWKSFMTNGL FVCIKGNIVP HRYRAGEFNF QISAIEMLSE MRKKKAKSLD
LRISTKSVDQ RLIDEVYKLF NDNVGTTPIK FKIYDTAHNM EVEMPSRSVR VDLTDELVKS
LKEYDMEVTL SDK
//
