ID A0A1I7D8G4_9BACT Unreviewed; 801 AA.
AC A0A1I7D8G4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFU07940.1};
GN ORFNames=SAMN04489724_3754 {ECO:0000313|EMBL:SFU07940.1};
OS Algoriphagus locisalis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=305507 {ECO:0000313|EMBL:SFU07940.1, ECO:0000313|Proteomes:UP000199673};
RN [1] {ECO:0000313|EMBL:SFU07940.1, ECO:0000313|Proteomes:UP000199673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23445 {ECO:0000313|EMBL:SFU07940.1,
RC ECO:0000313|Proteomes:UP000199673};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; FPBF01000006; SFU07940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7D8G4; -.
DR STRING; 305507.SAMN04489724_3754; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000199673; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..306
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 801 AA; 89732 MW; BDAF8EE362AF7AD6 CRC64;
MNRTIKKVAI LGSGVMGSRI ACHFANIGVQ VLLLDIVPFE LTEQEQKKGL TKEDPIVRNR
IVTSALQSTL KSNPSAIYDK AFASRITTGN FDDDLPKIKD YDWVMEVIVE RLDIKQSLFE
KVEKHRKPGT LITSNTSGIP MHMMCEGRSE DFQENFAGTH FFNPPRYLRL LEIIPGPKSK
QENIDFLMEY GDKYLGKETV LCKDTPAFIA NRIGVYAIIS AMHTIEKMGL GVSEVDKLTG
TIIGRAKSAT FRTMDVVGLD TTVNVANNLY KALPNDESRE KFKLPKIMEV LYEKKWLGDK
TGSGYFNMIR HEDGSKELKE IDFETFEYKE LEKPKFKALE ASKEFEDLKK RIKHLVNFDD
KAGEFYRATF YDLFRYCSFR IPEIADELFR IDQAVCAGFG WELGPFENWD LLGVKETVEK
MEAAGEKPAA WVYEMLEAGN ESFYTVENGK KHYYDIPSKS YKEVPGMDDF IILDTLKSAG
KVIWNNAGAS VYDLGDDVIG LEFHTKMNSM GQEVIEGINT AIGMAEKSYR GLVVGNEGAN
FSAGANLAML FMFAGDQDFD EINLMIAQFQ NTMMRARYSS VPVISAPHNM ALGGGCEFSL
HSDHIQAHAE LYMGLVEVGV GLIPAGGGTK EMTLRFSNAV KSGDVELNRL QDAFMNIAMA
KVSTSAEEAR NLGYLRKEDG ITLNRKRQLA EAKSKVLSLN EAGYTQPIEQ TDIRVLGKES
LALFEAGITG MRYGAYISEH DALIAKKLAY VMSGGDLSSP TEVSERYLLD LEREAFLSLT
GEKKTLERIH SILFKGKPLR N
//
