ID   A0A1I7ECI2_9BURK        Unreviewed;       366 AA.
AC   A0A1I7ECI2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:SFU21676.1};
GN   ORFNames=SAMN05192563_1016171 {ECO:0000313|EMBL:SFU21676.1};
OS   Paraburkholderia aspalathi.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=1324617 {ECO:0000313|EMBL:SFU21676.1, ECO:0000313|Proteomes:UP000198844};
RN   [1] {ECO:0000313|EMBL:SFU21676.1, ECO:0000313|Proteomes:UP000198844}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 27731 {ECO:0000313|EMBL:SFU21676.1,
RC   ECO:0000313|Proteomes:UP000198844};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; FPBH01000016; SFU21676.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7ECI2; -.
DR   Proteomes; UP000198844; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012824; CobW.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02475; CobW; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          261..355
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   366 AA;  39807 MW;  B4266A365D9DA92D CRC64;
     MQTQMRKIPV TIVTGFLGSG KTTLLRHILQ HAGGKRIAVI VNEFGELGID GEILKGCGIG
     CDENGVETEG QLYELANGCL CCTVQEEFFP VMEKLVERRE QIDHVLIETS GLALPKPLVQ
     AFNWPQIKNS FTVDAVVTVV DGPAAASGQF ADNPVAVDAQ RKADPNLDHE SPLHELFEDQ
     LSAADLVILN KTDLLDEARQ AAVEAVIREE IPPQVKIVRA QMGQLDLHTL LGLEAASEET
     IHLRHDHHGS AEDADHHHDE FDSVVVHANV SSREAVIAAL QGLVETNTIY RVKGFAALPG
     AAMRLVIQGV GRRFDSYFDR RWQAGETGAE QQSRFVLIGE DLDQAALQQA FDAALGAVAN
     AQPQQA
//