ID A0A1I7EYB0_9CLOT Unreviewed; 977 AA.
AC A0A1I7EYB0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=SAMN04487886_10027 {ECO:0000313|EMBL:SFU28901.1};
OS Clostridium sp. DSM 8431.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1761781 {ECO:0000313|EMBL:SFU28901.1, ECO:0000313|Proteomes:UP000198524};
RN [1] {ECO:0000313|EMBL:SFU28901.1, ECO:0000313|Proteomes:UP000198524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8431 {ECO:0000313|EMBL:SFU28901.1,
RC ECO:0000313|Proteomes:UP000198524};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; FPBY01000002; SFU28901.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7EYB0; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000198524; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152:SF2; DRUG RESISTANCE ABC TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198524};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 625..964
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 977 AA; 109250 MW; 92E0AE2734A10F53 CRC64;
MNILKEISMN NNCKNAYDPK DNNIIIQGAR QHNLKNVNIT LPKNKLIVFT GVSGSGKSTL
VFDSIYAEAQ RRFMAGVSAF ARRNLQKLEK PKFDFMYGLT PAIAIEQKGV GNNPRSTVGT
ITEISDYLRL LYSRIGIRHC TDCGTEIIPR TPKQICKSIF EKVREGEKLK LITAVSLDPR
INFKRDLEKL TAAGIHKLRI NGNVYDISDI LKNKIDSKVY AEVIGVLTIP QELKKHYDEY
LNKYSSIINK FVKLGNGTLK VENEGETLYF TTNSTCPKCY YNFPDLSSQH FSFNTPVGMC
PECGGLGVKQ AMLPESLIGD TKLSILDGAI KWYGVIRDSD KTTWPTGPLD VVFNHYGADI
ETPWEELPER LREVLLYGSG DEKLKYRSTL GNKDTFKSVP GLIPELTRLY YKSDSEFTRK
KYGAYMTSEP CSECNGTRLC KEARSVTING KTISEVSKMS VEDAITWIQE ACKEFDDDIF
KISSEILEEV TNRLLFLKKV GLKYLSLDRA APTLSGGEGQ RVRLAGQLSS GIMGIMYILD
EPSVGLHPRD LKSLVDTLLT LRDQGNTVLV VEHDEFIMQY ADMIVDVGPR AGELGGEIMS
HGTIDEIMND ENSLTGKYLS GKLIVGSDEW SKNSVDNCKW LSLKGVSHNN LRNIDVKFPL
GRFTCVTGVS GSGKSSLIQG VLRPLLEKLL NDEDTKPGKY KEIKGYEYLD KIIDVSQAPI
GRTPRSNPAT YTGVFDKIRK VFASTEYAKD NGLKADYFSF NSKKGCCEVC SGEGQIKIEM
HFLADIWVTC NECNGQRFKP EILACKYKGK NIADVLDLTV KEALDFFEGN REICRILQTL
CDVGLEYIKL GQSSVTLSGG EAQRIKLAKE ISKKTKEKMI YILDEPTTGL HFSDIQHLLD
IFKRLVKDGH TLIVIEHNID VIKSADWIVD IGPDGGVHGG EVVAEAYPKD LINVKESYTG
KALKKSLNWN SRKNFNS
//
