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Database: UniProt
Entry: A0A1I7FNV3_9BACL
LinkDB: A0A1I7FNV3_9BACL
Original site: A0A1I7FNV3_9BACL 
ID   A0A1I7FNV3_9BACL        Unreviewed;       802 AA.
AC   A0A1I7FNV3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   03-JUL-2019, entry version 14.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFU37882.1};
GN   ORFNames=SAMN05421543_101368 {ECO:0000313|EMBL:SFU37882.1};
OS   Alicyclobacillus macrosporangiidus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Alicyclobacillus.
OX   NCBI_TaxID=392015 {ECO:0000313|EMBL:SFU37882.1, ECO:0000313|Proteomes:UP000183508};
RN   [1] {ECO:0000313|Proteomes:UP000183508}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17980 {ECO:0000313|Proteomes:UP000183508};
RA   Varghese N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FPBV01000001; SFU37882.1; -; Genomic_DNA.
DR   RefSeq; WP_074948946.1; NZ_FPBV01000001.1.
DR   STRING; 1382304.JNIL01000001_gene3280; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000183508; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000183508};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183508}.
FT   DOMAIN        8    205       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      208    307       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   802 AA;  87549 MW;  06C809FD3C3F9B70 CRC64;
     MTRKIRRVGV IGAGVMGAAI AAHLANVGMS VVLLDIVPGE LTEDEAKQGL TLASKAVRNR
     IVNRGLQAAL RAKPASFYTE EDAGRIETGN LEDDLDRLAA CDWVIEAIVE NLEAKKALFA
     KLENVVREDA VVSSNTSGIS IAAMAEGRGE SFRRRFLGTH FFNPPRYMKL LEIIPGPQTD
     PELVSFMRRF GERVLGKGVV LAKDTPNFIA NRIGTYGLMV TLDAMRRFGL GVDEVDALTG
     PVMGRPKSAT FRTLDLVGLD TFVHVANNVR ASVADPAEKD AFTIPPYLER MVANGWLGEK
     TGQGFFKRVK GADGRREILA LDLETFEYRP RRRVQSPALE AAKNQPTAAL RLKTLVSGQD
     PASQFVWDVL KRVLLYTAER QGEIADDIVS VDNAMKWGFN WELGPYETWD AIGLQESVAR
     MRAEGERIPA FVEELLASGR TSFYERQPGE VPKFYVGAGK YRTVEEPAEV ISLARLKEQG
     RLVRGNRSAS LVDLGDGVLC LEFHSPKQAL GPDVVQMIHA AADEVSANWE ALVIGNQAPN
     FCVGANLMLM LMEAQDENWD EINLAVQQLQ QALMRIKYLD KPVVAAPFGY ALGGGAEVCF
     PADRIQASGE TYMGLVEVGV GLIPGGGGNK EMLIRAIEGA EGAADTRLDN FVRRAFENIA
     LAKVSTSARD AQRLGYLRKT DGITVGGDYL LHDAKQVALG LARAGYTPPT PRPIPVIGED
     GAAALKIGVY GMKKAGYISD HDEKIAHHLI RVLTGGSVRR GTLVSESYLL DLEREAFLSL
     IGEPKTQQRM QHMLQTGKPL RN
//
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