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Database: UniProt
Entry: A0A1I7HCK6_9BURK
LinkDB: A0A1I7HCK6_9BURK
Original site: A0A1I7HCK6_9BURK 
ID   A0A1I7HCK6_9BURK        Unreviewed;       695 AA.
AC   A0A1I7HCK6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=Short chain enoyl-CoA hydratase /3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFU58474.1};
GN   ORFNames=SAMN05216552_1005170 {ECO:0000313|EMBL:SFU58474.1};
OS   Massilia namucuonensis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Massilia.
OX   NCBI_TaxID=1035707 {ECO:0000313|EMBL:SFU58474.1, ECO:0000313|Proteomes:UP000199391};
RN   [1] {ECO:0000313|EMBL:SFU58474.1, ECO:0000313|Proteomes:UP000199391}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.11014 {ECO:0000313|EMBL:SFU58474.1,
RC   ECO:0000313|Proteomes:UP000199391};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FPBO01000005; SFU58474.1; -; Genomic_DNA.
DR   BioCyc; GCF_900116645:BM436_RS07800-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199391; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199391};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199391}.
FT   DOMAIN      296    472       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      477    569       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      605    691       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   695 AA;  74821 MW;  98ABEC51BEFC8AFB CRC64;
     MSAEYHVQGS VAVITLDNPP VNGLGHATRL AAVQGVQKAL ADDAVKAIVI TGAGKAFSGG
     ADIKEFNSPK ALAEPNLHSL IRTVEESTKP VVAAIHTVCM GGGLELALGC NYRVAMPGAQ
     IALPEVKLGL VPGAGGTQRL PRVLGLEMAL NMIVSGTPVA SEKLKGTALF DEMFAPDADL
     LASAVAFAGK VADARPLPRV RDIKVDYPNH EAFLQFSRNT VKAMSGPFPA PLECVECVAA
     TVTMKFEDGL KFERERFIAL IQTPESKSLR HAFFSERQAS KVPDVPADTP VRAIRKAAVI
     GAGTMGGGIA MNFANAGIPV TILEMKQEAL DKGLATIRKN YENTLKKGKL TQEKFDQRVG
     LITGSLSYEE IGDADIVVEA VFEEMGVKET VFRKLDEVMK PGAILASNTS TLDVDQIASF
     TKRPQDVVGT HFFSPANVMK LLEIVRGAKT GKEVLATTLA LSKKLKKTGV VSGVCDGFIG
     NRMIEQYSRQ AGFLLEEGCL PEQVDKAVEK FGFAMGPFRM GDLAGNDIGW YIRKRRYVES
     PEITYSKTAD LLCEMGRFGQ KTGGGWYDYK AGDRKAYPNE DVNAMIVKHS ADLGVERRKI
     SDQEIVERLV YALVNEGAKI VEEGIALRAS DIDMVYLTGY GFPLHRGGPM FYADTVGLPN
     VLGTIERLAR GRHGDAWKPA PLLVKLAAEG KGFNG
//
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