ID A0A1I7J5T3_9BURK Unreviewed; 523 AA.
AC A0A1I7J5T3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338};
GN ORFNames=SAMN05216350_105250 {ECO:0000313|EMBL:SFU80530.1};
OS Polaromonas sp. YR568.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=1855301 {ECO:0000313|EMBL:SFU80530.1, ECO:0000313|Proteomes:UP000217451};
RN [1] {ECO:0000313|EMBL:SFU80530.1, ECO:0000313|Proteomes:UP000217451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR568 {ECO:0000313|EMBL:SFU80530.1,
RC ECO:0000313|Proteomes:UP000217451};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941}.
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DR EMBL; FPBM01000005; SFU80530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7J5T3; -.
DR STRING; 1855301.SAMN05216350_105250; -.
DR OrthoDB; 9769623at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000217451; Unassembled WGS sequence.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW Lyase {ECO:0000313|EMBL:SFU80530.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..44
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 45..523
FT /note="argininosuccinate lyase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012317251"
FT DOMAIN 124..326
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 386..437
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 523 AA; 57396 MW; 5F3FC1187478053D CRC64;
MKPTESPFAS AFTPAFTLSL LPRSLGRLAL VPLLLASLSV AALAADKKGG KSDHDNFYFL
GEMNKASTVM VVETKIVPPD LGKKIALAVD QVIKNGNQPG AKRPGDYLQY EPLILALAGP
DGSRMHSGRS RQDILSTTRR LMQRERTLAL MEAMIQSKAQ LLEVAEKNLD TIVPAYTNGV
QAQPTTYAHY LLAFASVFGR DSTRLKEAYA RLNMSPLGAA ALGTSSFPVN RQRLAELLGF
DGPVENSYDA AQLGALDQGV ELVGLCSNAA LMMGVLVQDI HTQYHQTAPW IMIQEGRLTG
TSSIMPQKRN PYALNVLRLQ ASEVVGSAFT YQLEAHNVTP GMPDYKRDQV EKTLDLTTSA
FEKLADLMNN LIIDKNRALQ EVDADYSTTT ELADILQRDS DVPFRVGHHF ASDLVSYGRA
NKLKPADIPF DIVKQLYTDA VKTFNFAKTD FPLTQERFQK SLTAQNMLAS SKGLGGPQRA
ETVRMLAAEK AKLDQDSAWL KAQQDKLARA QDNLNRTFSK LGQ
//
