ID   A0A1I7JCZ5_9BACL        Unreviewed;       491 AA.
AC   A0A1I7JCZ5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE            EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE   AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN   ORFNames=SAMN05421543_109120 {ECO:0000313|EMBL:SFU83060.1};
OS   Alicyclobacillus macrosporangiidus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Alicyclobacillus.
OX   NCBI_TaxID=392015 {ECO:0000313|EMBL:SFU83060.1, ECO:0000313|Proteomes:UP000183508};
RN   [1] {ECO:0000313|Proteomes:UP000183508}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17980 {ECO:0000313|Proteomes:UP000183508};
RA   Varghese N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000799};
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000256|ARBA:ARBA00005297}.
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DR   EMBL; FPBV01000009; SFU83060.1; -; Genomic_DNA.
DR   RefSeq; WP_074952229.1; NZ_FPBV01000009.1.
DR   AlphaFoldDB; A0A1I7JCZ5; -.
DR   STRING; 392015.SAMN05421543_109120; -.
DR   OrthoDB; 9803598at2; -.
DR   Proteomes; UP000183508; Unassembled WGS sequence.
DR   GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   NCBIfam; TIGR00543; isochor_syn; 1.
DR   PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR   PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; ADC synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183508}.
FT   DOMAIN          219..472
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
SQ   SEQUENCE   491 AA;  52452 MW;  6AC347D22B1F9E34 CRC64;
     MARQLDIPLT GIAAALDALR PWTERAAERA RTLGRPVLAA VRVPLDPADD LLAAALACPP
     GVPRWYLHQP AAGRTWLGLG AVAAVRPGPA CALGGLADAW QAWRPLVETD VPEALHWVGG
     AAFDTGPRLD PWRGWPSAEM WLPRVMFTRD GDEAACTVAV QAVPGQSAAE VWAAAADGWQ
     RWSGVPPERA EDPGARLSAA SLARSDGDRR PGTAFEDARD RWMRLVAETA SAIRAGRFDK
     VVLAREEVVP LGRPADIAAA LRALGRRYPE SGVFALWRGD QCFLGATPER LARVGTGSVE
     VDCLAGTAPR GRTPAEDARL ADWLLHSGKN LHEHSVVREW LRARLAPLCT HLEIPAEPGL
     KRLANVQHLH TPLAGRLRAG QNILTVADAL MPTPALAGSP QKEAMAYIRD REGFDRGWYG
     GAIGWAGMDG SGEFMVAIRC ALVGSVSAHL YAGAGIMGDS DPAAEWEETV LKLRPMKQAL
     GLEVGDDGGE S
//