ID A0A1I7LHL0_9BURK Unreviewed; 730 AA.
AC A0A1I7LHL0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN ORFNames=SAMN05216552_102935 {ECO:0000313|EMBL:SFV09126.1};
OS Pseudoduganella namucuonensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Pseudoduganella.
OX NCBI_TaxID=1035707 {ECO:0000313|EMBL:SFV09126.1, ECO:0000313|Proteomes:UP000199391};
RN [1] {ECO:0000313|Proteomes:UP000199391}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.11014 {ECO:0000313|Proteomes:UP000199391};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC {ECO:0000256|ARBA:ARBA00005637}.
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DR EMBL; FPBO01000029; SFV09126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7LHL0; -.
DR STRING; 1035707.SAMN05216552_102935; -.
DR OrthoDB; 9806701at2; -.
DR Proteomes; UP000199391; Unassembled WGS sequence.
DR GO; GO:0004336; F:galactosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR010496; 3-keto-disaccharide_hydrolase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR049161; GH59_cat.
DR InterPro; IPR001286; Glyco_hydro_59.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR Pfam; PF06439; 3keto-disac_hyd; 1.
DR Pfam; PF02057; Glyco_hydro_59; 1.
DR PRINTS; PR00850; GLHYDRLASE59.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000199391};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..730
FT /note="galactosylceramidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011757326"
FT DOMAIN 44..358
FT /note="Glycosyl hydrolase family 59 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02057"
FT DOMAIN 538..669
FT /note="3-keto-disaccharide hydrolase"
FT /evidence="ECO:0000259|Pfam:PF06439"
SQ SEQUENCE 730 AA; 78843 MW; 3998EA1AE01AE3CE CRC64;
MRDRICGPLI LAAFAALAGP SAAADAPSSV QRIELKGDAG GKRFDGIGVV DGGGATSVLL
KDYPEPQRSQ ILDLMYKPKF GASVSALLVE IPGDGNATQG SMPSHMHTRD DLDYTRGYMW
WVMREAKKRN PALTLDGTAW SGPGWIGDQG NGFPQGGGKG EFFSTDAADY YVSWLKGLRE
VYGLEFDAIG SRNEKGVSYD FVKALRARLD AHGYGKVKIH SFDNWPDQSK YDFVKDMPGD
KALRDAIDII SAHVNVLDKS RVPPEVREAA AAMGKPLWNT EGHVYIAGYD GAIGVVRAFN
ENYVHNGITK IVNWYGIAGV YTTEPYAGDK EAAIRANWPW SGHYSLNPHV WAYAHYGQFT
EAGWTYLNGG SGELAGGGTF VTLKSPGKDY SVIIETREAK TPQPVRLEVG GGLSSGDVAV
WRSNEREQFV RLADVAPRNG VVALTLDPNS IYSLTTTRGQ QKGAFAEAPP LKAFPFPYRE
TFEQYARPRE WGHLPRYFAD IAGAFELASC PGGKGVCMRQ AVPVPTHSWA PDWKPYTIIG
DEQWSDYEVG ADVYLNPGEE AGVMGRVNHV GTGYGFIPKG YYLQLSDGGR AELVVVRGKA
DKKALVGDAE QQALIKAQND ASEGGEKVLA AARVAGVGAR RWHNLKLRFK GAAITGFVDG
KPVLTATDGL YGKGMAGVMA GADRQKLGMP YFDNVTVNRV DGPEPAASVA LPGQEPIYRA
SGSASARLPK
//
