ID   A0A1I7MHZ4_9MICC        Unreviewed;       392 AA.
AC   A0A1I7MHZ4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit {ECO:0000313|EMBL:SFV21527.1};
GN   ORFNames=SAMN04487966_102401 {ECO:0000313|EMBL:SFV21527.1};
OS   Micrococcus terreus.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Micrococcus.
OX   NCBI_TaxID=574650 {ECO:0000313|EMBL:SFV21527.1, ECO:0000313|Proteomes:UP000198881};
RN   [1] {ECO:0000313|EMBL:SFV21527.1, ECO:0000313|Proteomes:UP000198881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.7054 {ECO:0000313|EMBL:SFV21527.1,
RC   ECO:0000313|Proteomes:UP000198881};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FPCG01000002; SFV21527.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7MHZ4; -.
DR   STRING; 574650.SAMN04487966_102401; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000198881; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR017596; PdhA/BkdA.
DR   InterPro; IPR029061; THDP-binding.
DR   NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR   PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:SFV21527.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198881}.
FT   DOMAIN          60..313
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   392 AA;  42948 MW;  48546ACC10AD7631 CRC64;
     MGSVTLNTPP TGLPQLPEPD LLQLLSPEGT LSTEHDLDPW AVEVTPELLA ELHRHLTEIR
     RLDTEATHLQ RQGELALWPP LLGQEAAQVG SALALQEKDY IFPSYRENGA LYLRGVDPLG
     LIRMWRGSTF CGWAPSEHRV GAQQIIIGAQ SLHAVGYAMG AAMDGEASAT VAYFGDGATS
     QGDVNEAMVF AASYQAPVVF FCQNNHWAIS EPVGLQARRH IADRPWGFGI PSMRVDGNDV
     LAVLAATRRA TERARNGGGP TFIEAVTYRM GPHTTADDPQ RYRPEGELEA WRAKDPIDRV
     EKLIQRRGED LDAVKNASQQ AADALAARIR SGLAQSEEPG PAELFDHVYA EPHSELERQR
     EHYRLYLEQF GDHSLPARSD AAALSTASGT DH
//