ID   A0A1I7N2M2_9BACT        Unreviewed;       665 AA.
AC   A0A1I7N2M2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:SFV28888.1};
GN   ORFNames=SAMN05660895_0433 {ECO:0000313|EMBL:SFV28888.1};
OS   Thermoflavifilum thermophilum.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Thermoflavifilum.
OX   NCBI_TaxID=1393122 {ECO:0000313|EMBL:SFV28888.1, ECO:0000313|Proteomes:UP000199537};
RN   [1] {ECO:0000313|Proteomes:UP000199537}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14807 {ECO:0000313|Proteomes:UP000199537};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FPCJ01000001; SFV28888.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7N2M2; -.
DR   STRING; 1393122.SAMN05660895_0433; -.
DR   OrthoDB; 9778383at2; -.
DR   Proteomes; UP000199537; Unassembled WGS sequence.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199537}.
FT   DOMAIN          38..93
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          101..478
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   665 AA;  75462 MW;  FD45ADAF9DF7CD22 CRC64;
     MAEGEILWQP ADAIWQASHL AHYVQWLSRE KRLSFHDYTT LWQWSVRDIP AFWQSVWEYF
     KLPRLDEHVK VMSGDPMPYT RWFAGARLNY AAHVFKHATD QRPALWFAAE DKPLRPVSWQ
     TLLQHVAGLQ YFFQQVGLQK GDRVAAYLPN APEATIGWLA TVALGAVWSS CSPDFGVQGV
     LDRFRQIQPK ILIAADGYVY QGKRYDRQQQ LKSICEALPS LACVILVPRI HDEATWQDIH
     PKQVSWEDAV AGGSRRAPIS ADVQVVEVDF SHPLWILYSS GTTGIPKAIT HSHGGMLLEH
     LKYLAFHNDV HAGENFFWYT TTGWMMWNFL QASLLMGATA VLYDGHPAYP DMGVLWRLAA
     QLPIHHFGTS APFLMSCKKN GYRADDLDLA SLRSIGSTGS PLPAEGFEYV YQSIKSDVWL
     CSMSGGTDIC TAWVGGCLWR PVRSGEIQCR CLGCSMYAYD ENGKALDHEI GEMVVTAPMP
     CMPVYFWNDP DFTRYRESYF EMYPGVWRHG DWIRITEHDG VIIYGRSDAT LNRQGVRIGT
     AEIYRVLDRL PEIKDSLIVN IELPNGKSYM PLFVVLLPEI ELSIGLKQKI QEALRNSCSP
     RHVPDEIIAV DDIPYTISGK KLEMPVKKLF LGMPLEKVVQ PGVLRNPDAL QAFETLAQSW
     RSRFS
//