ID A0A1I7NAI6_9BACT Unreviewed; 422 AA.
AC A0A1I7NAI6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Hemolysin, contains CBS domains {ECO:0000313|EMBL:SFV31603.1};
GN ORFNames=SAMN05660895_1121 {ECO:0000313|EMBL:SFV31603.1};
OS Thermoflavifilum thermophilum.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Thermoflavifilum.
OX NCBI_TaxID=1393122 {ECO:0000313|EMBL:SFV31603.1, ECO:0000313|Proteomes:UP000199537};
RN [1] {ECO:0000313|Proteomes:UP000199537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14807 {ECO:0000313|Proteomes:UP000199537};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FPCJ01000001; SFV31603.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7NAI6; -.
DR STRING; 1393122.SAMN05660895_1121; -.
DR OrthoDB; 9798188at2; -.
DR Proteomes; UP000199537; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR43099:SF5; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199537};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..335
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 422 AA; 48753 MW; C7BFE315E815CEC3 CRC64;
MDTYQTSGLV VIILLLLTAF FTGIETAFFS ANKLSIEVRK KQGKWIGRIL NHFIQNPDQL
VGTCIVGVNI MLVIYGTVVF TALQPFWENL LLRGALNNPY LKLIVEILLS SFLILAFGEF
LPRILFKARA DFMLKIFLIP FYGFYTLFQP LVNALIGTAE WILIYLFNAR LSDRKLVFSK
MELHQFMHEN HYSVFHKELN TKWFENALAL VHVRIRECMV PRNEIVAIPL DSTLEEARQK
CIATRLSKII VYEDSIDQIC GYIHQLDFFS NPAHLKDILH SIPAVPETMR AVDLITKFSE
TRKTIAWVVD EFGGTAGIVT MEDVLEEIFG EFKDEHDQKG LVEQQIAERE YLFSGRLEID
YLNEKYQLGL PKKDSETLSG LIIAHHETIP REKERIIIDQ FEFEIISVSE TRIETVKLRV
LE
//
