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Database: UniProt
Entry: A0A1I7RVK5_BURXY
LinkDB: A0A1I7RVK5_BURXY
Original site: A0A1I7RVK5_BURXY 
ID   A0A1I7RVK5_BURXY        Unreviewed;       580 AA.
AC   A0A1I7RVK5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:BXY_0476700.1};
OS   Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS   xylophilus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC   Bursaphelenchus.
OX   NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_0476700.1};
RN   [1] {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_0476700.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21909270; DOI=10.1371/journal.ppat.1002219;
RA   Kikuchi T., Cotton J.A., Dalzell J.J., Hasegawa K., Kanzaki N.,
RA   McVeigh P., Takanashi T., Tsai I.J., Assefa S.A., Cock P.J.,
RA   Otto T.D., Hunt M., Reid A.J., Sanchez-Flores A., Tsuchihara K.,
RA   Yokoi T., Larsson M.C., Miwa J., Maule A.G., Sahashi N., Jones J.T.,
RA   Berriman M.;
RT   "Genomic insights into the origin of parasitism in the emerging plant
RT   pathogen Bursaphelenchus xylophilus.";
RL   PLoS Pathog. 7:e1002219-e1002219(2011).
RN   [2] {ECO:0000313|WBParaSite:BXY_0476700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   WBParaSite; BXY_0476700.1; BXY_0476700.1; BXY_0476700.
DR   Proteomes; UP000095284; Whole Genome Shotgun Assembly.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095284};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    580       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5009304964.
FT   TRANSMEM    319    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    379    402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    540    563       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    317       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      324    556       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   580 AA;  67803 MW;  EB90F1C04325BF27 CRC64;
     MTLFFVLLSF SLFQAALANP RENCHNALDA IEVQVIQDPK VDQQMRETIL NQVTKGFVGN
     QQNYNNFGSQ ECLKGVLYCT NIIRYNSSKV HHISAEAKPP LNRPTEYQTE EQRLLYHLMR
     TYERSVRPVR NASTTITVKL GMTLTNIFDI DEKSQVLTIN VWLDQEWKDE LLAWEPKQFS
     GITSIRLPCD TIWLPDILLY NNADDFTSGY MRSRAMVFYD GTVFWPPPTR LRSLCKIDVT
     YFPFDDQLCI LKFGSWSYHG FQLDLTNRST NIDLTNYVES GEFELVRVHQ KRRVVKYSCC
     DEPYPDITFY IHVRRKTLFY IHNIVFPCVM MSVLTLLVFY LPPDSGEKVG LGITVLLAFS
     VFVLAVAEKM PETSESLPLI GIYLTTIMFL TSISVVMTVL VLNFHHRGFM NEEVPEWIDE
     LFLNKLRRFV RMKKRRSSIL TKAAAPCNNK TSRRRPTIIS MNGVNKMDYE LVPNGVDKEE
     EHENNNHNMA LSHRMPDKLN VVEQTILTSL QELLQQQRYQ FQQETRAEKW RMVAEVIDRL
     LFHIFLVSTL LITVIMLLMI PLYRRLFYDD QFDEKLFGRM
//
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