ID   A0A1I7S6Y1_BURXY        Unreviewed;      2535 AA.
AC   A0A1I7S6Y1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Talin-1 {ECO:0000313|WBParaSite:BXY_0877000.1};
OS   Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS   xylophilus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC   Bursaphelenchus.
OX   NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_0877000.1};
RN   [1] {ECO:0000313|WBParaSite:BXY_0877000.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; BXY_0877000.1; BXY_0877000.1; BXY_0877000.
DR   eggNOG; KOG4261; Eukaryota.
DR   Proteomes; UP000095284; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR   GO; GO:0001726; C:ruffle; IEA:InterPro.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd10569; FERM_C_Talin; 1.
DR   CDD; cd17089; FERM_F0_TLN; 1.
DR   CDD; cd17090; FERM_F1_TLN; 1.
DR   CDD; cd12150; talin-RS; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.20.1420.10; Talin, central domain; 6.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR032425; FERM_f0.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037438; Talin1/2-RS.
DR   InterPro; IPR015224; Talin_cent.
DR   InterPro; IPR036476; Talin_cent_sf.
DR   InterPro; IPR049108; Talin_R4.
DR   InterPro; IPR015009; Vinculin-bd_dom.
DR   PANTHER; PTHR19981:SF1; RHEA, ISOFORM B; 1.
DR   PANTHER; PTHR19981; TALIN; 1.
DR   Pfam; PF16511; FERM_f0; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF01608; I_LWEQ; 2.
DR   Pfam; PF09141; Talin_middle; 1.
DR   Pfam; PF21692; Talin_R4; 1.
DR   Pfam; PF08913; VBS; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SMART; SM01244; IRS; 1.
DR   SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 2.
DR   SUPFAM; SSF109885; I/LWEQ domain; 4.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          86..417
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          2290..2528
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          456..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2515..2535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1040..1086
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2535 AA;  278735 MW;  7CA0B8C0AD63A583 CRC64;
     MVAITLDVLY QAKGVRKTMK FEPSNLVQDV VRISKEKVGA PGTAHDYGLI RLDDDPSKSY
     WLEGSKQLDY YLLRNGDVLE LQNKIRQIRV RAVDGSTVKT VNVDESKPVK DLMVTICGKM
     GLSNHEEYSL VRDARFAPLK RDQSLSSLNG DQQYNGNNTF MNTIGRRREK QVQQLRAKLH
     TDDDVCWLDS NRTLREQGIG EGEELILRRK FFVSDTNLNT NDPAQLGMLY AQCRDGVLDG
     THPVSREIAI KLAALQCAIE FGEYQEGVEK KINMRDLLPK EYAKAKEHEK NIVDEWKELI
     IYNEKVQLQK KYCEVCQSLP TYGVTFFLVK EKVPGKNKLI PRLLGVNKDS VLRVDEKSKQ
     VLKEWPLEQV RRYAPGAQLF TLDFGDYKDG YYCVKTPDGE KIAALISGYI DIILKKKKLA
     DHLGIEGDEG STMLEDQVAP ARATLIGHGE ITRPQQLQGL PQGALRSRSS TPSGLPNGAQ
     YGAVSGYVTT QEMPRGERVR YVNPRERAQR ALIGTIEATI RAVQEAEEEI QRPPQIDLLR
     FEPSRREWRV EVEKEAVSDR LAAMGAATAE VVQLTAIPDD TDSRVGTAIA TIGSNLPEMG
     RGVRELAHMM PEEERRGDLI EASRRLMNAF GTFIDKVRPD QNEKRANILS AASAVGETSH
     DVIKTMRDET HEDRQYHDQL IQRARNVATN TAGLVMHAKT ISSDCGNDGL KERVINSATQ
     TAFATSELVA CTRVVAPTIE HPSSQERLTE AAQNVSRTVE TLVEHSREAV QHSRSGNGQN
     QIGDLTAAAR QVTHALDDLI DHIRTSPRGQ GGHRRHEENY NYEEVLRSSN RVITGAQPQR
     DANQAIRHSR ILVEQFENGA EADPNQRDKL LNAARNVAQA TSNMITATQE AQSRPQEAEA
     QIALKSAAEN LVQATNAAAN ERIAEDSFRS LERAAKNASA AVTQTVSAVN SAQPHIHNHQ
     TVEELIIESQ ITSNHVRPVI TAIKESQAAA TPSDRFRAQS SLIYETEEFL PPASQLVDLA
     RRAVPEVKEP HSASNLQSTS QKLSTELATL RTTLNKARQL NYNQQLDHTE ELIRELDQAL
     QQTNRDVREG HIRPTAAAGD ASQRLNDAAR QVSSTLTQLV SAAQSADKQH VGASAMDVSN
     ALRRFTYNAQ EIAPSCGNNV DTFIGNTRNV VHDSGNIFVQ VRNQASPSRL RDSLNTVQAS
     IRQTLNVLPD HASIEEAVKK IAQAEHVQVS TSLDLRQAAG KLIEAASELI AGLRAPEQRG
     RVDHFVEAYI TFFAVTRTHI NEKVSELPVK REILENLEIS RNAAINVLER FSGAQLDPQS
     LVHTQQLSQS ARQLSESVTT IVNITSQEAP WVKECDNALR KIEAVRPILN EAIVPQNHNS
     YYESLDAVTE EAKRLGSGLS GMAHHARHGN GDELYKAVHQ AGDAVCGLAE NAVQSAYLIG
     AGHPQSVGGR PALFDVERLN RNLLAIQAIT EKIVNGQVET SDLVAEMQAI AAHASNVAQI
     CRDATERTSS STTKKQFTNC ARDITDITSK LIAAVKKLQA KPESIDHQQD VNERALELND
     AAHTLAQFVD RPDFTPNAAK ISAEGRQSQE PLLQSGRQML DASAKMFSTA KKLAVNATDA
     NTWQEIADNS RVVSESIKNL VTTIRDQAPG QADLDLAIEK LGALIRQLDR AALDAAQDQL
     PRSNISEQRV HQQIVYCTQT LLEHIDPLKA AAKSHAEQLG HEVREHVKST ETLVQSAVQA
     ASLSYDSDAQ NKFFEQCKTV VEAELKLMIA AKDAGGNPKA EQLHSVVDEW ANQLRRALSD
     LERSVNLLDS QAGVIHGIVE TITRSIAITD QSKAVDPSDS FPNVQARMVE GLEKIRKIAE
     DMPVRDVEDL GKDSLTLAEL YRTLAEDGRV ATSLLTNSDL SYKLKVSVQR LGTTSIELVR
     VAGQRRSHPY DERIRHDLQR SSEVVVERCE EVLAALYEGS RGTQACINAA NTVSGIIGDL
     DTTILFATSG SLNPASPQHQ PQSAKEHRDT IVRTAKALIE DTKALVTGAA SNQEQLAVAA
     QNSVRTIMQL TEAVRRGASV LSKDSQESRV LVFHACRDVA ASLSNLINAT NRASGRNPQD
     PAMSNLKDAA KTMVINVSNL LKTVKSFEEQ NRGGAYALEA AMDAIDFAVR QYDLNESPKR
     TDPATAEDVI RATREVTEAS TRATTMASAL DTERVIAASN FARKAVADLL STTLSASLNA
     DTPELGAKTK NAGREVAIQV KQLLQHLLAY VAQPANHSCK ELILLASQEV SNSVGILANC
     CEALRSNWST ERREPQNAIE AAENELLGAA SSIEAAAERL QHLKPRHQVQ NPDQELEFDV
     HIISYAKQIT NAVSALVKAA RSTQRELVQQ GRIDPRPQQF KGNDYQWSEG FVSAAKAVAA
     AVQQLCETAN SVVAGHASEE KLAACAKTVA AHTAQLLVAC RVKADQGSHN MQRLQSAGQA
     VRVAAESLVN AARQRVADDE RIVVINDRMV HGIAQVMKAQ EEVIRKEREL TEARRQLAQV
     NKSRYAPQDS DEDAA
//