ID   A0A1I7SSC8_BURXY        Unreviewed;       921 AA.
AC   A0A1I7SSC8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Degenerin-like protein unc-105 {ECO:0000313|WBParaSite:BXY_1594500.1};
OS   Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS   xylophilus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC   Bursaphelenchus.
OX   NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_1594500.1};
RN   [1] {ECO:0000313|WBParaSite:BXY_1594500.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A1I7SSC8; -.
DR   WBParaSite; BXY_1594500.1; BXY_1594500.1; BXY_1594500.
DR   eggNOG; KOG4294; Eukaryota.
DR   Proteomes; UP000095284; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        127..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        720..741
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          883..910
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..796
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        797..814
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   921 AA;  103888 MW;  6F0A26B32091732F CRC64;
     MSSSNSDAAT SNGPPGLGRS SRSVSGVPRQ RTYSRQNSEE STRRRPLHPA EKKAAQLRLP
     QGSFEKKPSS PAHAMNALRR LSRADFSSIR RAKLSGHLNY RQIWQRFGRQ TTIHGISHAA
     TAPTKQWVYL WIAAFIVCFI ALVVQIIFLI HKYLQYAKTV DLDLKFENAP FPSVTLCNLN
     PYKASMIGQD PATRAMMSSF QNVMKSGSVA EGIATVIAQT RERRRLRRQL NGTISEDRRY
     LQVYAQCYCE INRLSGERRS GSCFGVHKGK IALSFIDNNL HNFHPTRCLC QLDWTSKALW
     PCFPYNTWKE KICTECVPDL GHCPMRFYHG KQDKKKLQGD LDICLCHKEY NHCIANNENG
     EIPEILPTFD VDHMNFTQAF VTAKPKKVGP TTTTTTEAPA VREALGYEEL KNDISIATQA
     RENIKFAVGE KNESAKVDMS QNMDELILEC TFNQRDCEIK KDFRLTHDAT FGNCYTFNWD
     RTKDVTAHRA GANFGLRVLL YANVSEYLPT SESVGFRITV HDKWVVPFPD AFGHTAPTGF
     MSSFGVRMKQ FYRIAPPHGK CKDGGEEEDR YIYKNYKYSV EGCHRSCTQY EIVKTCGCAD
     PSYPIPNGTT MCKLTDPAAR NCIKNTTQLM GRMIAEANIC KCHQPCSELG YEVSYSAARW
     PSGTTKLREC HLGDDMCMEK YRKNAAMIQI FFEELNFETL TESPAYTWNS FLADLGGMSG
     LWIGASVVSV LELASLAFYV AQAYVRKRKK STSTLTSIRN KSVPVSKKIS LQSQQSSVIY
     RPRTPTPSTT KSRLSLLNDD PDPEPMKLEA GSDEQDPEPE PSDDAHSKSS YPYWPPGQEL
     PCTCLYNSNG NIISMKALCP EHGYMVRRGT MYCCGEEEEE GAGEEITNEE EQMQEAIDVL
     QANLYNLKNE RGLSKQKSQD S
//