ID   A0A1I7SU76_BURXY        Unreviewed;      1094 AA.
AC   A0A1I7SU76;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|WBParaSite:BXY_1659800.1};
OS   Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS   xylophilus).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC   Bursaphelenchus.
OX   NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_1659800.1};
RN   [1] {ECO:0000313|WBParaSite:BXY_1659800.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR   AlphaFoldDB; A0A1I7SU76; -.
DR   WBParaSite; BXY_1659800.1; BXY_1659800.1; BXY_1659800.
DR   eggNOG; KOG1141; Eukaryota.
DR   Proteomes; UP000095284; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR041291; TUDOR_5.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF18359; Tudor_5; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          811..884
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          887..1069
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          1078..1094
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          969..989
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        973..987
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1094 AA;  127400 MW;  57E5A72B45CF2DE3 CRC64;
     MDVPINTSFL NLLDKLSLDS KNELDARITS IYWNARCMKG NVVQNNGNRT EFPFELSKDI
     VSKLSEFGVH EVQRHYEMDI FDIVSAFCDF FFNNLVEHVD DITVDFYSIA RQLYISQNDL
     MDFVVLLLEA TDDGELSLEK MYLNHLWDPQ RILLFCTYIH VGIHRPGHIY DLEKFKFLEY
     DKLHKPSLTN VLYETLGGLE NTKRILETID PKYFQLQVEN YVLPELAQMF SALNVNKDAF
     LESKKALVKE MEEAALDDFE LHSIPELDLV GESSSSNMEV FKKMTEYKLC DHISLDYEKK
     MNIGRHEKLW VEMDEKFHEG HLHSWLHDEE EDRITHVKVE IKVRSRKIVR EVDASRVARA
     SPVGAMCNAG TRVLAKYKGI DENKWKWGTL GTFPIKEYRF HYLVFFDDGT VQFIRPKNLY
     LCIVQPKAPN SDDFSPVFAY KYVKGVRSAF LKHYFSLYPS WPLMNVQLNT SMLVNREVGK
     KKTAVKAMVI QKDRCLLLVR FLTEFDEYKE CKEYPCSDHS HQDEWIFAGD TMRIPTLKNI
     LAKVETATDL NTYPEKVREY IEMLYPKYEV DDVKEFSILD KCKVKNTARK TGNKKEPSFF
     DFFNNAKNHH INVDQRKNVG DGEGCSKDQL IPEYLEYPNW DHLHRRPHST CSSECLLEIR
     NCHLVGKHAY KDVPAFFRPF LYGFRRISLV YFDVEVRDDN DEEKNVETVF VYEAPCGRLL
     RSLDEVAFYL HVTKSELISI DQFTFRIWDR PNFIYRSDPK YLVDPDFAHC KEAITIPTVN
     SVDDEGPPLM LYQSSRCMDE PLLETQMEFT SCCSCTDDCL NSDTCECQLL TKETHQRLDE
     RIRSEIPDGY KFRRLERKLF SGVYECNMGC SCSTNCLNRV VQRDICVPMQ LFKTAKKGWG
     VRTLVDIPQG QFVCTYSGQM FTDVKADEHV RKGQGSDMYF ADVDLFDSVE GMKMNLNIPY
     PDDEGIEVEE KKNRKKKRKR NKWTHQKRGR SPVITDEKTL LHHLFGESRL FVVDAQERGN
     LGRFFNHSCD PNMEVQMVFS DTHDIRLPMI AFFTSCDVEA GTELCWNYGY VAGSVPGKVI
     ECSCGSVNCI GRIL
//