ID   A0A1I7SXU1_9PELO        Unreviewed;       809 AA.
AC   A0A1I7SXU1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
OS   Caenorhabditis tropicalis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold171.g650.t1};
RN   [1] {ECO:0000313|WBParaSite:Csp11.Scaffold171.g650.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC       ECO:0000256|RuleBase:RU369091}.
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DR   AlphaFoldDB; A0A1I7SXU1; -.
DR   STRING; 1561998.A0A1I7SXU1; -.
DR   WBParaSite; Csp11.Scaffold171.g650.t1; Csp11.Scaffold171.g650.t1; Csp11.Scaffold171.g650.
DR   eggNOG; KOG2118; Eukaryota.
DR   Proteomes; UP000095282; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:UniProt.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:1905941; P:positive regulation of gonad development; IEA:UniProt.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..809
FT                   /note="Metal transporter"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009306832"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        284..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   DOMAIN          195..374
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          392..454
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          460..527
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          735..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..754
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   809 AA;  88999 MW;  8252D8AD85F9701A CRC64;
     MSASCLLLIL TISLSFHVAT AQNGVDDEVT TVAGILDSAT TAAQAIDNST ITPQSINNNT
     NTGIKTPTIF GMRVELPADD PFGYDKHGVC SVTPEEEFKV VIYGNHLDKI HQIIWTFTNN
     CSEPAYVIDA LNHFKIHFNH KATFHLTLKL LPEMVHAYKM CVKPKVAQGA PPLGEIYPLD
     DISTWLTTER PPKEYFLPLP LQISCIGFLL VLSALFSGLT LGLMSLTPQE LELVIKSGAV
     KEQKCAAKIL PIRKKGNLLL CSLLLGNVIV NSAISILMGE LTTGIYALIG STLGIVIFGE
     ILPQSICVKK GLEVGAHTIS ITQLFIIVTY PIAWPVSKLL DCLLGDEYQA YDRKRLMELV
     KMSITDNGQV ANELKIAVGA MEIADKVVKD VMTKIDDVFM LPDTTVLNAK TVMEIVKMGY
     TRIPVYQFGD KNNVTDMLFV KDLALLDPDD NFTVKTVCGY HKHPVKFVMN DTPLPHLLEA
     FKKGEGHLAM VKRSVGGTEG HEAYELVGVV TLEDIVEEIL QAEINDEFDI VTDNVNKVKI
     KKDPNRDATK YFGDHEAPQT MISMQLQMVA LQWMVSNERA FGLEFLDTNV LERLIRSSAR
     RVDVSALMAM GDDAINVPRL AKVYTKEEPS DKYILILEGR IQVTIGASGM MFEAGPWHHF
     GGEIMAKMVD GAATLGRSMS IVGTSDLSAR RPDLMFRPDY SAVVKEDCTY LEISVAAYIN
     AYKASLMQRE KPLTDASDVS HNSSAHNSTL SLAEKPGPIT DPSAMLVPEN IRKPSLVSVE
     TQPKILNLIG QHPVAPVAEE EEMALLDKI
//