ID   A0A1I7TKC7_9PELO        Unreviewed;       536 AA.
AC   A0A1I7TKC7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:Csp11.Scaffold627.g6766.t1};
OS   Caenorhabditis tropicalis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold627.g6766.t1};
RN   [1] {ECO:0000313|WBParaSite:Csp11.Scaffold627.g6766.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A1I7TKC7; -.
DR   STRING; 1561998.A0A1I7TKC7; -.
DR   WBParaSite; Csp11.Scaffold627.g6766.t1; Csp11.Scaffold627.g6766.t1; Csp11.Scaffold627.g6766.
DR   eggNOG; KOG4294; Eukaryota.
DR   Proteomes; UP000095282; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF296; PROTEIN CBG11983; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        375..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          514..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  61298 MW;  C57279C0A0585BEC CRC64;
     MKYRTRLLHP VQPSEICPIL TLNSTKDLSD DLLDYLMMFN SDAMTLYGRA DGQSLHSGDN
     IYKQYVSSHP NFTADGFFMD AGFSCGDMFK MCSFGGRRFD CCKYATPIFS DLGKCFTLNV
     QSSDKPWMKM QTEPGIAAGL QIILDSHLEE QFDSETDGVT PVFSSAFENG FRYYVHSSEE
     IPFLASEGIA VSPDSVVYSA LSSSKYILLS SSSWGNCSDS WPPGYDQNFP YTSAMCSTIC
     KAQHFQKLCG CSPSIYNHLN RFNDCTPYET YRCMDTKMKK VVNQTTLNIE MPTCEECRVE
     CKSQVYHSFN SYGKGLSRGA LMWLSKQGDW RIQHMKSNFQ VVNVFFRDMS YTEYIQKRGM
     SLTELLSDIG GNMGMFMGMS VFTIIELSLF LSKIGWIAFS RKRRDYMYSK KKNEEMHEKE
     LEDVVTGFKL FRTRKSGNDM SHLREKIKGL SMHRVTSEQL NVCKLAWENE PDIERRLAIV
     TRQNSALKEH KDHKESTILP FDLKDIKEQI SRGRAASMFR TRRSRSETAP SAIHDA
//