ID A0A1I7TYX5_9PELO Unreviewed; 978 AA.
AC A0A1I7TYX5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|WBParaSite:Csp11.Scaffold629.g13180.t1};
OS Caenorhabditis tropicalis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold629.g13180.t1};
RN [1] {ECO:0000313|WBParaSite:Csp11.Scaffold629.g13180.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A1I7TYX5; -.
DR STRING; 1561998.A0A1I7TYX5; -.
DR WBParaSite; Csp11.Scaffold629.g13180.t1; Csp11.Scaffold629.g13180.t1; Csp11.Scaffold629.g13180.
DR eggNOG; KOG1306; Eukaryota.
DR Proteomes; UP000095282; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878:SF65; NA_CA-EXCHANGE PROTEIN, ISOFORM G; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..978
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009308144"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 952..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..459
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 490..589
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 608..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..774
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 108811 MW; 8F4E1D3E4000ED73 CRC64;
MTRLGCWLAV ASLVALTGLA DAGSNCSAAD ATRNCIDGLV VPIWRPFLDL TTQDRVIRGV
LYFFVIAYMF LGISIVADRF MSSIEVITSM ERTIVVKRPG LDPMAVQVRI WNDTVSNLTL
MALGSSAPEI LLSIIEVIAR GFEAGDLGPN TIVGSAAFNL FMIIAICVVV IPKGEIRRQK
HLDVFCVTAT WSIFAYVWLY LILAFFSPGE IEIWEGLLTF IFFPLTVGTA YMADIKIIQN
RFLPHRYRRG SHGQMIATEA EEMKMLENGS PQGAADPALK AFEEHRQEFI ELMREIRKQN
PHITPTELQK QAEYEMISRG PKSRAFYRVQ ATRRLIGGGD IVKKRIDKEH NKALDALVQS
QEKQLRDNTC KIFLDPAHYT VLESVGSFDV VVGRDGGPEG LTVMVDYFTE DGTANAGSDY
IPVKGTLTFY PEDKHQKVTI EVVDDDVFEE DEHFYLRLTN LRVRTKDGII IDPTRIGGLP
VAQLEMPNTA TIMILDDDHA GVFGFDHDHF QVVENCGHLS LQMKRHSGAR GKVVIPFRTV
EGTAQADKHF EMKEGEIVFE DNQTEATIDI GIIDTEQYER SDYFYIELSP PIWAKKMNDL
SRIQERFQRR MERKRGSSVA SESKDSNTDT ALAPTDKSTR AASVDLLQPS SDPRRSSQSN
SPHLTSRFRN RLGSWIAGMK GGDDEVTTSL TPSQLEIAEM GKPRLGEFTK CQITIRESKE
FQGIVDRMIK NANTRIMLGT HSWREQFMEA LVVSAGDDDD DDEEGDDGED KEPEEPGCMD
YFMHVLTVPW KLTFATIPPT DYLGGWATFV VAIFMIGVLT AVVGDLASQF GCWVGLKDAV
TAISFVALGT SVPDTFASKV SAVQDKYADN AVGNVTGSNA VNVFLGIGIA WSMAAIYHWN
KGTKFLVDPG NLGFSVLIFC VEALLCIAVL VLRRSKRVGG ELGGPPALRW MTSMFFCSLW
LMYLLLSALE AYCIIPGF
//