ID A0A1I7U6D5_9PELO Unreviewed; 1477 AA.
AC A0A1I7U6D5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=DH domain-containing protein {ECO:0000313|WBParaSite:Csp11.Scaffold629.g15316.t2};
OS Caenorhabditis tropicalis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold629.g15316.t2};
RN [1] {ECO:0000313|WBParaSite:Csp11.Scaffold629.g15316.t2}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR STRING; 1561998.A0A1I7U6D5; -.
DR WBParaSite; Csp11.Scaffold629.g15316.t2; Csp11.Scaffold629.g15316.t2; Csp11.Scaffold629.g15316.
DR Proteomes; UP000095282; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 241..444
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 505..602
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 652..820
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 901..1161
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1161..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1294
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1370
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1437
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1477 AA; 168811 MW; 7506D0E69EF33A06 CRC64;
MSVSLASSDT VSLTSRKTIS TNKYWSAIFD ERIYQICNIV HPGLPIDLDA VEHIRYFLQS
IVSELIESRA TSVVEVEKSA KKLFGYGLGS VCKDAKDNMN QQLQKHKYQK TLKTVLESQH
RLAAVIKETL GPREKEKKDR EKKEIEKCAC YIYYACESVT EDVLRLTGNY VKNIRNSEQK
ITMANLDVAL NADRALMELR TKLRNEEEAE SPGGFGVLSD FEEFVAEETE HPGKSSSNSQ
TYESVAVDFL RDERRFIREL NRINVFRRRI ESVATSESDK NIVYNLFGNL HEIHELALKI
ERTLEDAIEL NDTQCIGMGI WEYGEAYEFD TYTFYIKRDG DLNESRHATY VIYDNIKALL
ENERFSQLFQ SGEHLNASSL DGQSFRLAVQ YVLPQLLHIP IYHIYQYHEY INKLHQLSSS
EEDRRDLNDC RSAFDRVVGS VSDMSTELKS KIASFLDQQA KSEKIYNVKR LNEIQSSIDG
FAGSPIGKTC NELEKDGDLG MIRPSPQLNG EITKNKKWKT ERFVYVFDQM IILCKRHKNS
LKFKDRLAVH SIDVFDVPDT EAMNCFKIES HDKSCLPRIY YFVCRNAEEK RQWMAVLVKV
TTKSVLDRIL DNYEKEEAKR IPLIVPGSDQ YRFSEPDTED NISFEDYTSS SGIPVIKCGT
VLKLIERLTY HSYTDSKYIQ TFLISYRSFC TPNDLFSLLL ERFNIPTPKK LQRPKQGGGP
LAGRFDTVQS HGLSTIASST GINPLYEQKF RKEFQQPIQL RVLSVINQWV KQHWYDFQCD
PVLLDALELF LNRCCDPREG LTKQHKKFCK TILALIEKRV KNPPGFLQPQ VENGENGDEG
HINNAFVFGD DQQHQLQQQQ QQVYANNSPT ESNQFASKRP EILWHTAQKG DVDHYDLLTL
HPLEIGRQLT LLHFDLYRAI QPIELVEAAW TKSEKWRKSP QLLRLTDHST LLTYWVSRSI
VETESLEERM AMFNRVLEVM SVFEELHNFT GLVAFYSALN SSCIFRLKWC WERLDSEKQK
CFDRFNTLCE RRWHEMQKRL SSINPPCIPF FGHYLSNIYF LEQGNSTFVN KQPAGLKNKD
DVKSTDPDNN KQFKQLVSFL KCRKISDVIR EIQIYQNERY SLTLEPTIRQ FFESINPKND
FKSNEELEDY LYQKSLEIQP KGVDTPTTEV KPKHPASTLR SPGIKPPKNG NHYTPNHPHG
LHLHSQHSHS APHNIAAAHQ SNTVPNTPIT SHETKRSLSQ NNQEEAQFSM VDVRYDRKGT
HQKIPVLQPP PLVPRPRHHP SAASLPPTTQ APMPPAPKSS GMTSSASSPS STSTTPVSAF
GPAPKLYPRR GPQPMSPLAK SPLTPSKDNS PSAFQFPYVS PPPLPPRPSS SSDASSPSTS
SVSAAAKENQ EQLRVIFDRE ESHSPTVRLS VPLPPALPPP RGSSVFRMPP PLPPKSNRHN
SSSPTSSEPF EDPTSPSIFV NTPPPPLPPK TYRVSKK
//
